Proofreading and Repair
REFLECT AND APPLY Given the typing speed from Question 1, how long must you type, nonstop, at the fidelity shown by E. coli (see Question) before an uncorrected error would be permitted?
Question
Proofreading and Repair
REFLECT AND APPLY E. coli incorporates deoxyribonucleotides into DNA at a rate of 250 to 1000 bases per second. Using the higher value, translate this into typing speed in words per minute. (Assume five characters per word, using the typing analogy from Question.)
Question 1
Proofreading and Repair
REFLECT AND APPLY Your book contains about 2 million characters (letters, spaces, and punctuation marks). If you could type with the accuracy with which the prokaryote E. coli incorporates, proofreads, and repairs bases in replication (about one uncorrected error in 109 to 1010 bases), how many such books would you have to type before an uncorrected error is “permitted”? (Assume that the error rate is one in 1010 bases.)
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