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Solutions For An Introduction to Medicinal Chemistry Chapter 19 Problem 10Q

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Solution 1

Ciprofloxacin belongs to quinolone and fluoroquinolone. The drug shows antibacterial activity. It works by attacking the nucleic acid material of the cell. These are basically used to cure urinary tract infections.

Quinolones are of different structures, but ciprofloxacin is found to be the best amongst other analogues due to its structure. As compared to other analogue the ciprofloxacin consist of cyclopropane attached to first nitrogen.

It gives broad spectrum properties to the ciprofloxacin. The nitrogen is replaced by carbon and decreases its adverse action. These properties differentiate ciprofloxacin from other analogues.

The fourth analogue is similar to ciprofloxacin, but this analogue shows better resemblance to a third-fourth generation of antibiotic. This antibiotic is found to show effective action than another. The levofloxacin with nitrogen is attached with cyclic ring. The cyclic structure gives stability to the structure.

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Solutions For Problems in Chapter 19