Question

Match the terms with their appropriate definitions 1. The pattern of histone modification acts much like a language or code in specifying alterations in chromatin structure. (Click to select) 2. Enzymes which acetylate the positively charged lysines within the core histone proteins. (Click to select) 3. Enzyme which attaches a methyl group to the number 5 position of the cytosine base, forming 5-methylcytosine. (Click to select) 4. Proteins which bind methylated sequences. (Click to select) 5. The methylation of DNA that was previously unmethylated. (Click to select) 6. Hemimethylated DNA is recognized by DNA methyltransferase, which makes it fully methylated. (Click to select)

Answer 1

1. Histone code hypothesis :-

the pattern of histone modification acts much like a language or come in specifying alterations in chromatin structure

2. Histone acetyltransferases :-

enzymes which acetylate the positively charged lysines within the core histone proteins

3. DNA methyltransferase :-

enzyme which attaches a methyl group to the number 5 position of the cytosine base, forming 5-methylcytosine

4. Methyl-CpG-binding proteins :-

proteins which bind methylated sequences

5. De novo methylation :-

the methylation of DNA that was previously unmethylated

6. Maintenance methylation :-

Hemimethylated DNA is recognized by DNA methyltransferase, which makes it fully methylated