Question

please show work

The ampicillin monograph states that the reconstituted suspension is stable for 14 days in a refrigerator. If the product is left at room temperature for 6 h, what is the reduction in the expiration period?

Answer 1

The question here states that H Life at 25°C for 6h = how many hours at se If refrigerator temperature is 5°C. This can be calculated using formula troct.) = where tquct2) = enpiration times at temperature Tz tqo (Ts) = expiration time at temperature Ti Qio values is taken 2,3,4,5 differently to check out.

. Now a=2 6h = 0.25 (in days) tqo Lt) = ? So, tao D a 0.28 days, Q10=2 tqolti) ? tqo ctyy x(Q..) (!)0 25-5/10 = 0,25% (2) - 0-25% (2)? = 1 day ; two cty = 0.25x(3)?: 0.25x9 = 9.25 days at Q10 = 4, tgo (T) = 0.25%(4) = 0:26X16 = 4 days at Q10 =5, To CT) = 0.25x(s)? = 6.25 days tao (T) = 1 day ( possible) So - at af at dip=2 dio=3 Q10 24 , tqo CT,) = tao (Til = 2,25 days 4 days ( likely) ( conservative)