9) 9) Why do aldehydes undergo nucleophilic addition reactions, whereas esters undergo nucleophilic acyl substitution reactions?...
Why do aldehydes undergo nucleophilic addition reactions while acyl chlorides undergo nucleophilic acyl substitution reactions? Once the nucleophile adds to the aldehyde, the tetrahedral intermediate is too sterically hindered to eliminate one of the attached groups. Because an Sw2 substitution can best take place on the sphybridized carborwyl carbon of the acyl halide. Once the nucleophile adds to the aldehyde, neither H" nor Rºcan function as a leaving group. so a substitution cannot take place. The carbonyl carbon of the...
Why do esters, carboxylic acids and amides undergo acyl substitution but aldehydes and ketones cannot?
Paragraph Styles 6. ... 7 1. Why is an ester less reactive to nucleophilic acyl substitution than an acid chloride? A) Chloride is a better leaving group B) Oxygen is better at donating electron density into the carbonyl with added resonance stability. C) Chloride is a better leaving group and compared to chlorine, oxygen is better at donating electron density into the carbonyl with added resonance stability D) The alkoxy anion is less basic than the chloride anion. 2. What...
Can you help me identify reagent (i), Compound 8 and Compound 12 in the reaction scheme? You have laboratory data on all the compounds in the synthesis, however the amount of data available to you varies. Some have the entirety of the spectral data, others have as little as the elemental analysis. Use the laboratory data to help you discover which reaction has been performed. The lab data for Compound 8 and 12 is as follows: You can use any...