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Paragraph Styles 6. ... 7 1. Why is an ester less reactive to nucleophilic acyl substitution...
Why do aldehydes undergo nucleophilic addition reactions while acyl chlorides undergo nucleophilic acyl substitution reactions? Once...
Why do aldehydes undergo nucleophilic addition reactions while acyl chlorides undergo nucleophilic acyl substitution reactions? Once the nucleophile adds to the aldehyde, the tetrahedral intermediate is too sterically hindered to eliminate one of the attached groups. Because an Sw2 substitution can best take place on the sphybridized carborwyl carbon of the acyl halide. Once the nucleophile adds to the aldehyde, neither H" nor Rºcan function as a leaving group. so a substitution cannot take place. The carbonyl carbon of the...
9) 9) Why do aldehydes undergo nucleophilic addition reactions, whereas esters undergo nucleophilic acyl substitution reactions?...
9) 9) Why do aldehydes undergo nucleophilic addition reactions, whereas esters undergo nucleophilic acyl substitution reactions? A) The carbonyl carbon of an ester is more electrophilic than that of an aldehyde. B) Once the nucleophile adds to an aldehyde, neither H- nor R-can be eliminated because they are strongly basic. C) Aldehydes are more sterically hindered than esters. D) The ester carbonyl carbon is sp3 hybridized while the aldehyde carbonyl carbon is sp2 hybridized. E) Once the nucleophile adds to...
References [Review Topical Acyl transfer (nucleophilic substitution at carbonyl) reactions proceed in two stages via a...
References [Review Topical Acyl transfer (nucleophilic substitution at carbonyl) reactions proceed in two stages via a "tetrahedral intermediate." Draw the tetrahedral intermediate as it is first formed in the following reaction CH3OH H2SO4 (trace) reflux • You do not have to consider stereochemistry • Include all valence lone pairs in your answer. • Do not include counter-ions, e.g, Na, I. in your answer. • In cases where there is more than one answer, just draw one. - -O0O- (Review Topical...
LINE Topics (References) Acyl transfer (nucleophilic substitution at carbonyl) reactions proceed in two stages via...
LINE Topics (References) Acyl transfer (nucleophilic substitution at carbonyl) reactions proceed in two stages via a "tetrahedral intermediate." Draw the tetrahedral intermediate as it is first formed in the following reaction. H3CO CHz + (CH3)2NH • You do not have to consider stereochemistry • Include all valence lone pairs in your answer. • Do not include counter-ions, e.g., Na,r, in your answer. • In cases where there is more than one answer, just draw one. Acyl transfer (nucleophilic substitution at...
(7 points) Explain why esters are more reactive towards nucleophilic acyl substitution compared to amides. Your...
(7 points) Explain why esters are more reactive towards nucleophilic acyl substitution compared to amides. Your answer should be clear and concise. Writing more than necessary only increases the odds of writing an incorrect statement, which could result in points off. nucleophilic acyl substitution Nu R X R Nu - - - - - - - - - - O RO R NO Ester Amide
OH H+ CH3 H3C OH Esters can be synthesized by an acid-catalyzed nucleophilic acyl substitution between...
OH H+ CH3 H3C OH Esters can be synthesized by an acid-catalyzed nucleophilic acyl substitution between an alcohol and a carboxylic acid; this process is called the Fischer esterification reaction. Because the alcohol oxygen is a poor nucleophile, the carbonyl carbon is made a better electrophile by protonation of the carbonyl oxygen. The steps of the synthesis are all reversible. The reaction is generally driven to completion by using an excess of the liquid alcohol as a solvent, or by...
1) What is the main intramolecular force between two molecules of propanoic acid? A) hydrogen bonding...
1) What is the main intramolecular force between two molecules of propanoic acid? A) hydrogen bonding B) London dispersion forces C) dipole-dipole interaction D) induced dipole interactions 2) Acetyl chloride undergoes nucleophilic acyl substitution faster than methyl acetate because A) methoxide ion is a better leaving group than chloride ion. B) the ester is more sterically hindered than the acyl chloride. C) chloride ion is a better leaving group than methoxide ion. D) esters hydrolyze faster than acid chlorides. 3)...
can someone tell me which ones are correct, and the correct anwser? What is the correct...
can someone tell me which ones are correct, and the correct
anwser?
What is the correct nucleophile for the reaction? HN ribose 0.01:03 ATP NH3 CH3NK2 NH2 Move to Archive ® Saved What is the product formed by hydrolysis of the following lactone with acid? Multiple Choice Move to Archive ® How can you convert a carboxylic acid into an acid chloride? Multiple Choice React with sodium chloride. O React with Cl2 and FeCl3. Heat with hydrochloric acid. React with...
1. 2. JUST DRAW ARROWS... (CH3)2Culi + CH3Cu Ph CI Ph CH3 The ketone intermediate formed...
1.
2.
JUST DRAW ARROWS...
(CH3)2Culi + CH3Cu Ph CI Ph CH3 The ketone intermediate formed in the reaction of an acid chloride with a Grignard reagent cannot be isolated because it reacts too rapidly with the second equivalent of Grignard reagent. To produce a ketone from an acid chloride, one can treat the acid chloride with a lithium dialkylcopper reagent. The reaction occurs by nucleophilic acyl substitution on the acid chloride by the dialkylcopper anion to yield an acyl...
Questions 2-10 please!! 1) A substitution reaction is: [2] a) A reaction during which an OH...
Questions 2-10 please!!
1) A substitution reaction is: [2] a) A reaction during which an OH group of a molecule is replaced by a halogen. b) A reaction during which water is the leaving group. c) A reaction during which a functional group of a molecule is replaced by an electrophile. d) A reaction during which a functional group of a molecule is replaced by another functional group. V 12 2) Substitution reactions are classified either as electrophilic or nucleophilic...
Why do aldehydes undergo nucleophilic addition reactions while acyl chlorides undergo nucleophilic acyl substitution reactions? Once the nucleophile adds to the aldehyde, the tetrahedral intermediate is too sterically hindered to eliminate one of the attached groups. Because an Sw2 substitution can best take place on the sphybridized carborwyl carbon of the acyl halide. Once the nucleophile adds to the aldehyde, neither H" nor Rºcan function as a leaving group. so a substitution cannot take place. The carbonyl carbon of the...
9) 9) Why do aldehydes undergo nucleophilic addition reactions, whereas esters undergo nucleophilic acyl substitution reactions? A) The carbonyl carbon of an ester is more electrophilic than that of an aldehyde. B) Once the nucleophile adds to an aldehyde, neither H- nor R-can be eliminated because they are strongly basic. C) Aldehydes are more sterically hindered than esters. D) The ester carbonyl carbon is sp3 hybridized while the aldehyde carbonyl carbon is sp2 hybridized. E) Once the nucleophile adds to...
References [Review Topical Acyl transfer (nucleophilic substitution at carbonyl) reactions proceed in two stages via a "tetrahedral intermediate." Draw the tetrahedral intermediate as it is first formed in the following reaction CH3OH H2SO4 (trace) reflux • You do not have to consider stereochemistry • Include all valence lone pairs in your answer. • Do not include counter-ions, e.g, Na, I. in your answer. • In cases where there is more than one answer, just draw one. - -O0O- (Review Topical...
LINE Topics (References) Acyl transfer (nucleophilic substitution at carbonyl) reactions proceed in two stages via a "tetrahedral intermediate." Draw the tetrahedral intermediate as it is first formed in the following reaction. H3CO CHz + (CH3)2NH • You do not have to consider stereochemistry • Include all valence lone pairs in your answer. • Do not include counter-ions, e.g., Na,r, in your answer. • In cases where there is more than one answer, just draw one. Acyl transfer (nucleophilic substitution at...
(7 points) Explain why esters are more reactive towards nucleophilic acyl substitution compared to amides. Your answer should be clear and concise. Writing more than necessary only increases the odds of writing an incorrect statement, which could result in points off. nucleophilic acyl substitution Nu R X R Nu - - - - - - - - - - O RO R NO Ester Amide
OH H+ CH3 H3C OH Esters can be synthesized by an acid-catalyzed nucleophilic acyl substitution between an alcohol and a carboxylic acid; this process is called the Fischer esterification reaction. Because the alcohol oxygen is a poor nucleophile, the carbonyl carbon is made a better electrophile by protonation of the carbonyl oxygen. The steps of the synthesis are all reversible. The reaction is generally driven to completion by using an excess of the liquid alcohol as a solvent, or by...
1) What is the main intramolecular force between two molecules of propanoic acid? A) hydrogen bonding B) London dispersion forces C) dipole-dipole interaction D) induced dipole interactions 2) Acetyl chloride undergoes nucleophilic acyl substitution faster than methyl acetate because A) methoxide ion is a better leaving group than chloride ion. B) the ester is more sterically hindered than the acyl chloride. C) chloride ion is a better leaving group than methoxide ion. D) esters hydrolyze faster than acid chlorides. 3)...
can someone tell me which ones are correct, and the correct
anwser?
What is the correct nucleophile for the reaction? HN ribose 0.01:03 ATP NH3 CH3NK2 NH2 Move to Archive ® Saved What is the product formed by hydrolysis of the following lactone with acid? Multiple Choice Move to Archive ® How can you convert a carboxylic acid into an acid chloride? Multiple Choice React with sodium chloride. O React with Cl2 and FeCl3. Heat with hydrochloric acid. React with...
1.
2.
JUST DRAW ARROWS...
(CH3)2Culi + CH3Cu Ph CI Ph CH3 The ketone intermediate formed in the reaction of an acid chloride with a Grignard reagent cannot be isolated because it reacts too rapidly with the second equivalent of Grignard reagent. To produce a ketone from an acid chloride, one can treat the acid chloride with a lithium dialkylcopper reagent. The reaction occurs by nucleophilic acyl substitution on the acid chloride by the dialkylcopper anion to yield an acyl...
Questions 2-10 please!!
1) A substitution reaction is: [2] a) A reaction during which an OH group of a molecule is replaced by a halogen. b) A reaction during which water is the leaving group. c) A reaction during which a functional group of a molecule is replaced by an electrophile. d) A reaction during which a functional group of a molecule is replaced by another functional group. V 12 2) Substitution reactions are classified either as electrophilic or nucleophilic...
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