Question

Please explain step by step. Not too sure about how to start and go with this pedigree

The accompanying pedigree concerns a rare inherited dental abnormality, amelogenesis imperfecta (1 1レ17 E. What mode of inheritance best accounts for the transmission of this trait? Be specific and define your gene symbols F. Write, in the pedigree diagram, the genotypes of all family members according to your hypothesis, so far as they can be determined.

Answer 1

Answer

E) The above pedigree chart is showing inheritance of X linked recessive trait. Because the parents are asymptomatic for the trait but their offspring particularly males are frequently affected. Whereas females are spared.

F) consider the

Dominant normal gene is X^D

And recessive gene for disease is X^d

So genotypes of all family members

1) X^DY

2)X^D X^d

​​​​​​3) X^DY

4) and 8) X^DY

5) and 7) and 11) and 13) X^D X^D/X^DX^d

6) 9) 10) 12) X^DY