Question

Explain The pathophysiology mechanism of inflammatory bowel disease

Answer 1

Ans) Inflammatory Bowel Disease:

- An umbrella term referring to certain chronic diseases that basically cause inflammation of the intestines.

The two main types of IBD are:

- Crohn's Disease (CD)
- Ulcerative Colitis (UC)

Crohns and ulcerative colitis are differentiated based on

- Clinical
- Pathologic
- Endoscopic findings

Two main differences between ulcerative colitis and crohns

- Anatomic site
- Depth of bowel wall involvement

Pathophysiology of Inflammatory bowel disease:

• Genetic predisposition alters the mucosal immune system or barrier function.
• When environmental antigens are exposed to the mucosal immune system the type of antigen and the genetic makeup of the individual affect the type of T cell that is generated.
• The balance between cytokines is disrupted in favor of pro inflammatories inflammation continues unchecked an damage to colon is extreme.