Consider the molecule. Identify the molecule. NH2 FMN O NAD+ NADH OFMNH+ -P- 0 ΤΗ ОН...
0 0 2- но е H+ Q02- NAD NADH H20 OH он u Lam 00c NH3+ + H20 Coo +H3N COO +H3N COO- H coo 3-Phospho- glycerate 2. There are three metabolites produced through this pathway that are important for the cell. Two of them are amino acids (identify the amino acids by name). Discuss the role of the third significant product in metabolism.
3. The structure of nicotinamide adenine dinucleotide in its reduced form (NADH) is indicated here. CH2-O-P- 07 OH OH Он он a. Describe the structural relationship to of NADH to adenosine diphosphate (ATP). b. When NADH serves as a reductant (as it does in many biological applications), the compound delivers a hydride to the chemical species that to be reduced. Identify the source of hydride in NADH, and draw the structure of the oxidized form of NAD, the oxidized form...
What is the name of this nucleotide? NH2 -0—P- LH он он o deoxyguanosine 5'-monophosphate (dGMP) o adenosine 5'-monophosphate (AMP) o guanosine 5'-monophosphate (GMP) o deoxycytidine 5'-monophosphate (dCMP)
Picarate dehydrogenase (PDH) catalyzes the reduction of
dextoacetate to picarate, while oxidizing NADH to NAD+.
The overall reaction and the active site of PDH is shown below. Use
curved arrow notation to propose a reasonable reaction mechanism
for this reaction.
НО, o НО 0 + NADH + H+ LOH + NAD+ picarate dehydrogenase 6/ 0 dextoacetate picarate C- NADH NH2 ZI H2C Arg171 CH2 + NH3 NH3 Arg 102 go dextoacetate CH2 HN HC His 195
,0+2015MADHE 5. (8 points) Consider the oxidation of a mole of NADH: 083 V NAD +20 +H - NADH E' =-0.32 V What is the AG for the oxidation of a mole of NADH by oxygen? How many moles of protons are pumped as a result of the oxidation of a mole of NADH? If all of the protons could be used for ATP production by an ATP synthase with 10 c subunits, how many moles of ATP could be...
Classify the following reactions. Explain your choices.
+ CO2 NH2 ATP NH2 NH он + O R2 NH 0 0 0 0 0 NH glutathione NH 0 OH OH O OH HO он OH OH OH OH glucose-6-phosphate fructose-6-phosphate HO он cis-aconitic acid isocitric acid OH 8.
In one step of glycolysis, glyceraldehyde 3-phosphate is oxidized by NAD+ to yield 3-phosphoglycerate and NADH. 1) Consider that reaction, in the direction written. Which chemicals) is(are) losing electrons, and which chemical(s) is(are) gaining electrons? It's best to answer this in a clear complete sentence. 2 2 2 Table 10-2 Standard Reduction Potentials for Redox Pairs of Biological Relevance* Redox Pair Number of (oxidized form → reduced form) Electrons E.(V) acetate pyruvate 2 -0.70 succinate → a-ketoglutarate 2 -0.67 acetate...
8 n.) OCH3 Brz, FeBry 0.) + p.) ОН 1. NaNO2, HCl(aq) 2. CUNO2, NaNO2 NH2 9.) 1,3-butadiene r.) ОН 1. NaNO2, HCl(aq) 2. CuCN NH2
labelNeed help labeling the
numbers.
doo FAD FADH, HO Ha NAD NADH, H COA COA COA COA H3 H 1 2 3 H2 н. 4 18 ΝΗ P-ribose COO COA HN-H COA нс Hac FOA 10 11 +H2O 5 Ç00 CH o COO- HC "OOC ç -OH сн. coo 14 CH2 coo OOC NADH + HS 6 9 NAD 15 HES COO- 17 CEO нсон Çooº H2C P-ribose OOH HO CH C-0 CH CH2 coo coo 8 7 coo COA-S....
1 point Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor for many metabolic reactions. Lack of the precursor to NAD+, niacin, results in the human disease called pellagra, thus humans have evolved salvage pathways to breakdown and re-synthesize NAD+ when needed. Below is the chemical structure of NAD+. Enzymes catalyze reactions in parts of the protein called an active site. This portion of the protein forms favorable weak interactions with the substrate and stabilize the transition state, which is crucial...