Question

3. The structure of nicotinamide adenine dinucleotide in its reduced form (NADH) is indicated here. CH2-O-P- 07 OH OH Он он a. Describe the structural relationship to of NADH to adenosine diphosphate (ATP). b. When NADH serves as a reductant (as it does in many biological applications), the compound delivers a hydride to the chemical species that to be reduced. Identify the source of hydride in NADH, and draw the structure of the oxidized form of NAD, the oxidized form of NADH.

Answer 1

Solution:- (a) Structural relationship between NADH and adenosine diphosphate (ADP). :- strutwee of NADM iſ as follows:- NHL = N 'cuto-P-O-P-0- - O ogoh ---- on ADP moiety = structure of Adenosine diphosphate (ADP) :- NH2 = -P -O-P-O - O no on # NAD Chicotinamide adenine dinucleotide) exist in two forms in o An oxidised form (NAD) O A reduced form (NADH). NADH consist of two nucleotide units joined thorough theit s'- phosphate quois, one nucleotide containing an adenine base and the other containing nicotinamide.

Adenosine diphosphate (ADP) is essential for the flow of in living cells. NADH contains one ADP Cadenosine dejohosphate mode structwie. b) NAD+ acts as a hydride donale o essential for the flow of energy mosine diphosphate moiety) in its NI * * OH OH OH OH NH2 NHL O=P-09OV 0 A o-P-04 -0 - OH OH ои ои (NADH Reduced form NADE oxidised form