Question

Acetylcholinesterase is an enzyme that catalyzes the breakdown of acetylcholine and other choline esters that act as neurotransmitters. Acetylcholinesterase is one of the most viable therapeutic targets to date for symptomatic improvement in Alzheimer's disease as cholinergic deficit is a common finding in Alzheimer's disease. A new compound that acts as an acetylcholinesterase inhibitor is in preclinical drug development and being assessed as a possible treatment for Alzheimer's disease. Which of the following parameters would give an indication about the potency of this new compound? O EC50 o Imax O IC50 ОКі Emax Olo Ο Κd

Answer 1

The following are the parameters indicating the potency of new acetylcholenesterase inhibitor compound with description:

IC50 value indicates the concentration of acetylcholenesterase inhibitor which is required for 50% inhibition , Kd value indicates the afiinity of acetylcholenesterase inhibitor for the receptors, low kd value indicates , higher affinity for the receptors, also Ki value indicates about how potent the acetylcholenesterase inhibitor is.