Homework Answers
The correct order of antigen processing pathway for endogenous antigens are:
- Class 1 MHC peptide binds to CD8 +T cell.
- Alpha chain of class 1 MHC binds peptide.
- Alpha chain of class 1 MHC binds beta 2 microglobulins.
- Peptides are transported into endoplasmic reticulum by TAP
- Endogenous antigens within cytosol is degraded by proteasome
- Peptide class 1 MHC is transported to Golgi complex and then to cell surface.
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Handout IG2-2 Class I MHC-Peptide Interactions Place the steps of the antigen-processing pathway for endogenous antigen...
Handout IG2-3 class Ma601 MH-Pepide Interactions place the steps of the antigen-processing pathway for exogenous antigens...
Handout IG2-3 class Ma601 MH-Pepide Interactions place the steps of the antigen-processing pathway for exogenous antigens in the correet CLIP fragment is exchanged for antigenic peptide. Invariant chain is degraded, leaving CLIP fragment Class II MHC peptide complex binds to CD4 T cell. Class II MHC antigenic peptide is transported to cell surface. Class II MHC binds invariant chain to block binding of endogenous anti MHC complex goes through Golgi complex. Exogenous antigen is taken in and degraded and routed...
Another exaumple of haptens body to Per response occurs wi The best known example of Handout...
Another exaumple of haptens body to Per response occurs wi The best known example of Handout IG2-1 Categorization Categorize the characteristics in the following list with the appropr complex (MHC) class Expressed on all nucleated cells .Peptide-binding cleft is closed at both ends Presents endogenous antigen to CD8+ T cells . Has one alpha chain and beta:-microglobulin . Peptide-binding site holds peptides between 8 and 11 amimacrophages cells, and thymic epithelium) ting cells (B lymphocytes, monocytes, macrophages, dendritic . Has...
The transporter in antigen processing genes encode subunits of a heterodimer pump that transports peptides from...
The transporter in antigen processing genes encode subunits of a heterodimer pump that transports peptides from the cytosol into the endoplasmic reticulum, where they can associate with newly translated Class la chains O B-2 microglobulin. Proteosomes. Immunoglobulin molecules. Class Il a and B chains. Question 20 5 pts Soluble proteins are examples of: Bone marrow dependent antigens. Bone marrow independent antigens., Thymus dependent antigens. Thymus independent antigens. Good food. The features of bound peptide fragments isolated from different class molecules...
Identify which of the following statements is true regarding the transporter associated with antigen processing (TAP)...
Identify which of the following statements is true regarding the transporter associated with antigen processing (TAP) TAP is composed of three identical subunits TAP is a membrane-bound transport protein TAP transports proteasome-derived peptides from the cytosol directly to the lumen of the Golgi apparatus Peptides transported by TAP bind preferentially to MHC class II molecules Question 4 (2 points) All of the following are included in the peptide-loading complex except ERp57 B roglobu
Identify which of the following statements is true regarding the transporter associated with antigen processing (TAP)...
Identify which of the following statements is true regarding the transporter associated with antigen processing (TAP) TAP is composed of three identical subunits TAP is a membrane-bound transport protein TAP transports proteasome-derived peptides from the cytosol directly to the lumen of the Golgi apparatus Peptides transported by TAP bind preferentially to MHC class II molecules Question 4 (2 points) All of the following are included in the peptide-loading complex except ERp57 B roglobu
Given that HLA class I and II molecules are both synthesized within the endoplasmic reticulum (ER),...
Given that HLA class I and II molecules are both synthesized within the endoplasmic reticulum (ER), why are cytosolic (i.e. endogenous) antigens not loaded onto (or bound to) HLA class II molecules within the ER? a. ER resident aminopeptidase (ERAP) cannot trim peptides sufficiently to fit into the restricted peptide binding site (8-11 amino acids) HLA class II b. Invariant chain blocks peptide loading of HLA class II c. Endogenous antigens have no transporter to move them into the ER...
answer all the questions answering one question is not helpful 1. A helper T cell is...
answer all the questions answering one question is not helpful 1. A helper T cell is capable of helping another cell because it expresses a protein on its surface that binds to a different protein on the surface of the cell being helped. What are these proteins (on the T cell, and on the cell being helped)? CD28, and B7 TNF, and TNFR Class I MHC, and TCR CD40L, and CD40 CTLA-4, and B7 2. Helper T cells are restricted...
20. Defective function of which of the following proteins will result in failed antigen presentation to...
20. Defective function of which of the following proteins will result in failed antigen presentation to CD8 T cells? a. HLA-DM b. TAP c. Cathepsins d. CD1d 21.True or False: An antibody proteolytically cleaved by pepsin yields a fragment with higher avidity to the cognate antigen than an antibody cleaved by papain. a. True b. False 22.The structure recognized by an antibody (that is, the epitope) is the ________ and the regions of the antibody with significant sequence variation are...
Could you help with any of these ? and provide an explanation so I'll understand? thank...
Could you help with any of these ? and provide an explanation
so I'll understand? thank you so much
Circle all that apply 1) A patient has inherited two defective genes for TAP2 (remember the case study from before) Which of the following are true? (circle all that apply): - The patient will have a scarcity of CD4+ T helper cells -MHC class I molecules will not be expressed to any extent on the patient's cells -MHC class II molecules...
ANSWER ALL THE QUESTIONS FULLY AND CORRECTLY!!! 1) A patient has inherited two defective genes for...
ANSWER ALL THE QUESTIONS FULLY AND CORRECTLY!!!
1) A patient has inherited two defective genes for TAP2 (remember the case study from before) Which of the following are true? (circle all that apply): - The patient will have a scarcity of CD4+ T helper cells -MHC class I molecules will not be expressed to any extent on the patient's cells -MHC class II molecules will be reduced in expression - The patient will have an impaired ability to fight viral...
Handout IG2-3 class Ma601 MH-Pepide Interactions place the steps of the antigen-processing pathway for exogenous antigens in the correet CLIP fragment is exchanged for antigenic peptide. Invariant chain is degraded, leaving CLIP fragment Class II MHC peptide complex binds to CD4 T cell. Class II MHC antigenic peptide is transported to cell surface. Class II MHC binds invariant chain to block binding of endogenous anti MHC complex goes through Golgi complex. Exogenous antigen is taken in and degraded and routed...
Another exaumple of haptens body to Per response occurs wi The best known example of Handout IG2-1 Categorization Categorize the characteristics in the following list with the appropr complex (MHC) class Expressed on all nucleated cells .Peptide-binding cleft is closed at both ends Presents endogenous antigen to CD8+ T cells . Has one alpha chain and beta:-microglobulin . Peptide-binding site holds peptides between 8 and 11 amimacrophages cells, and thymic epithelium) ting cells (B lymphocytes, monocytes, macrophages, dendritic . Has...
The transporter in antigen processing genes encode subunits of a heterodimer pump that transports peptides from the cytosol into the endoplasmic reticulum, where they can associate with newly translated Class la chains O B-2 microglobulin. Proteosomes. Immunoglobulin molecules. Class Il a and B chains. Question 20 5 pts Soluble proteins are examples of: Bone marrow dependent antigens. Bone marrow independent antigens., Thymus dependent antigens. Thymus independent antigens. Good food. The features of bound peptide fragments isolated from different class molecules...
Identify which of the following statements is true regarding the transporter associated with antigen processing (TAP) TAP is composed of three identical subunits TAP is a membrane-bound transport protein TAP transports proteasome-derived peptides from the cytosol directly to the lumen of the Golgi apparatus Peptides transported by TAP bind preferentially to MHC class II molecules Question 4 (2 points) All of the following are included in the peptide-loading complex except ERp57 B roglobu
Identify which of the following statements is true regarding the transporter associated with antigen processing (TAP) TAP is composed of three identical subunits TAP is a membrane-bound transport protein TAP transports proteasome-derived peptides from the cytosol directly to the lumen of the Golgi apparatus Peptides transported by TAP bind preferentially to MHC class II molecules Question 4 (2 points) All of the following are included in the peptide-loading complex except ERp57 B roglobu
Could you help with any of these ? and provide an explanation
so I'll understand? thank you so much
Circle all that apply 1) A patient has inherited two defective genes for TAP2 (remember the case study from before) Which of the following are true? (circle all that apply): - The patient will have a scarcity of CD4+ T helper cells -MHC class I molecules will not be expressed to any extent on the patient's cells -MHC class II molecules...
ANSWER ALL THE QUESTIONS FULLY AND CORRECTLY!!!
1) A patient has inherited two defective genes for TAP2 (remember the case study from before) Which of the following are true? (circle all that apply): - The patient will have a scarcity of CD4+ T helper cells -MHC class I molecules will not be expressed to any extent on the patient's cells -MHC class II molecules will be reduced in expression - The patient will have an impaired ability to fight viral...
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