Question

20. Defective function of which of the following proteins will result in failed antigen presentation to CD8 T cells? a. HLA-DM b. TAP c. Cathepsins d. CD1d

21.True or False: An antibody proteolytically cleaved by pepsin yields a fragment with higher avidity to the cognate antigen than an antibody cleaved by papain. a. True b. False

22.The structure recognized by an antibody (that is, the epitope) is the ________ and the regions of the antibody with significant sequence variation are the ______ a. Complementaritydeterminingregion,Constantregions b. Antigenicdeterminant,Hypervariableregions c. Major histocompatibility complex (MHC), Complementarity determining regions d. Antigenbindingsite,Frameworkregions

23.True or False: The framework region (FR1, FR2, FR3) of the antigen receptor of B cells and T cells is most critical in antigen recognition and specificity. a. True b. False

24.An epitope composed of amino acids from different parts of a polypeptide chain brought together by protein folding are called _______ and can be recognized by _______ a. Linearepitopes,theTcellreceptor(TCR)onTcells b. Continuousepitopes,onlyantibodies c. Conformational epitopes, the B cell receptor (BCR) on B cells and antibodies d. Discontinuous epitopes, theT cell receptor(TCR)on T cells, B cell receptor (BCR) on B cells and antibodies

25.True or False: The peptide-binding clefts of MHC class I bind peptides of shorter length compared to those bound by MHC class II. a. True b. False

Answer 1

22. The structure recognised by an antibody is the Antigenbinding site ,    and the regions of the antibody with significant sequence variation are the frame work regions. 20 HLA-DM    21 True 23 True 24 An epitope composed of aminoacids from different parts of a polypeptide chain brought together by protein folding called Linearepitopes an can be recognised by the Tcell receptors (TCR) on cells 25 FALSE