Question

Question 5 (2 points)

Which is the most appropriate sequence of events in B cell signaling?

Question 5 options:

	A) Antigen binds BCR, intracellular receptor kinases (such as Fyn, Lyn or Blk) are activated, Syk is recruited to ITAMs on Igα/Igβ.
	B) Antigen binds BCR, Syk is recruited to ITAMs on Igα/Igβ. intracellular receptor kinases (such as Fyn, Lyn or Blk ) are activated,
	C) Syk becomes activated, the BCR can now bind an antigen, and intracellular kinases are activated.
	D) Intracellular receptor kinases (i.e. JAKs) are activated, antigen can now bind to the BCR, Syk is recruited to ITAMs on Igα/Igβ.

Question 6 (2 points)

Follicular dendritic cells are somewhat specialized antigen presentation cells and are found primarily:

Question 6 options:

	A) in the peripheral blood
	B) in the primary lymphoid organs
	C) in the secondary lymphoid organs
	D) in synovial fluids
	E) none of the above

Question 7 (2 points)

Of the following, which should NOT occur in order to facilitate T-cell selection in the thymus?

Question 7 options:

	A) positive-selection based on an interaction with MHC alone
	B) negative-selection based on a failed interaction with self-peptides in a MHC
	C) apoptosis of T-cells that fail to interact with MHC alone during positive selection.
	D) negative-selection based on an interaction with MHC containing a non-self peptide

Question 8 (2 points)

CTLs use the following membrane-bound protein interactions to “kill” a target cell through apoptosis:

Question 8 options:

	A) IL-2/IL-2 receptor
	B) CD4/MHC II
	C) TCR/MHC II
	D) Fas/FasL

Question 9 (2 points)

Which of the following is NOT a professional antigen presenting cell (i.e. doesn’t express MHCII)?

Question 9 options:

	A) neutrophil
	B) B cell
	C) dendritic cell
	D) macrophage
	E) all of the above are professional antigen presenting cells

Question 10 (2 points)

Which of the following describes a cytokine that typically cause a leukocyte to undergo extravasation (also called diapedesis or transendothelial migration)?  

Question 10 options:

	A) allergens
	B) haptens
	C) chemokines
	D) complement

Answer 1

5. B cell signalling:

- intracellular receptor kinases (Blk,Fyn,Lyn) are activated

- ITAMs on Igα and Igβ are phosphorylated

- Syk is recruited to ITAMs on Igα/Igβ.

So, the correct option is (A).

6. Follicular dendritic cells are found primarily in the germinal enters of secondary lymphoid organs.

So, the correct option is (c).

7.