Question

please answer all 4 questions

Question 11 3 pts A B-cell may be activated by: O A TEH cell O Another B-cell O A cytotoxic T-cell O A natural killer T-cell Question 12 3 pts What happens to centrocytes that have high-affinity (tightly-binding) antigen receptors after somatic hypermutation? They receive survival signals from TFH cells o They cannot process antigen or present it to TFH cells o They undergo phagocytosis by dendritic cells in the "light zone" o They die by apoptosis Question 13 3 pts All cells in a T cell lymphoma come from abnormal, excessive division from one original activated T cell. If you examine the T cell receptors of these lymphoma cells, which of the following is most likely? o Each individual cancer cell will express a different isotype switching events after activation cell receptor due to independent o All of the T cell receptors will bind to the same antigenic peptide and the same MHC molecule o Each individual cancer cell will express a different T cell receptor due to independent somatic hypermutation events after activation Each individual cancer cell will express a different T cell receptor due to independent V(D) recombination events Question 14 3 pts Which of the following is applicable to both class switch recombination and somatic hypermutation? o Dependent on activation-induced cytidine deaminase O Increases the affinity of antibody-antigen binding o Takes place in the bone marrow before antigen stimulation O Involves sequence changes in the constant regions only

Answer 1

The correct answer is:

11 : b) another b cell

12: they receive survival signals from TFH cell

13: each individual cancer cell will express a different T cell receptor due to independent recombination event.

14: takes place in the bone marrow before antigen stimulation