Question

Question 15 3 pts Null mutations in which of the following would allow antigen receptor production but reduce junctional diversity? Ligase O AID Tdt Rag2 Rag1 Question 16 3 pts What happens to centrocytes that have high-affinity (tightly binding) antigen receptors after somatic hypermutation? They receive survival signals from TFH cells They cannot process antigen or present it to TFH cells They undergo phagocytosis by dendritic cells in the "light zone" They die by apoptosis

Answer 1

1. The null mutation occurrence in the Tdt enzyme will allow the receptors to be made but with reduced junctional diversity due to the absence of N addition nucleotides after recombination is done by RAG. Hence the correct answer is TdT.

2. The centrocyte are the cells that are present with antigens to test for antigen binding affinity. If the affinity is low then they are apoptised and if the affinity is high then they recieve positive selection signals from the T cells. Hence the correct answer is: They recieve survival signals from the TFH cells.

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