Question

please answer all 4 questions :)

Question 7 3 pts Which of the following occur in both B cells and T cells? o isotype switching O somatic recombination o alternative splicing to produce different isoforms of the receptor o alternative splicing to produce a secreted form of the receptor o somatic hypermutation Question 8 3 pts Multiple factors that increase antigen receptor diversity also increase formation of non- productive alleles. Which of the following would generate a non-productive allele? Select all correct. O Generation of a stop codon at the junctions Net addition of nucleotides that are not multiples of 3 at the junctions Net addition of nucleotides that are a multiples of 3 at the junctions Junctional diversity that generates a receptor that bind self antigens Question 9 3 pts MHC I and MHC II differ from each other in that: O MHC I, but not MHC II, primarily present exogenous antigens to CD8+ T cells O MHC I, but not MHC II, is necessary for T cells to activate B cells O MHC I, but not MHC II, is necessary for T cells to kill cells presenting endogenous antigen O MHC II, but not MHC I, primarily present endogenous antigens to CD4+ T cells Question 10 3 pts How are the development of T cells and B cells different? o Only B cells lacking productive rearrangements of their receptor genes undergo apoptosis o Only T cells with with antigen receptors that recognize self antigens undergo apoptosis. o Only B cell antigen receptors are generated through rearrangements in their receptor-encoding genes o Only T cells require antigen receptor binding to MHC molecules during their development

Answer 1

Option B correct A incorrect gsotype switching occur ration, Somatic recombination occur in both T and B cell matwration. VCD) J orecombination is mechanism of somatic che combination. SO option B correct с incorrect as com .binatorial joining Junctional and insertional diversification оссия both in Band T cell d and e corret Somatic hypermutation Occuey only in B cells זין