Question

Is the first one correct and answer the second question please.

Which of the following does NOT occur in the germinal center? O phagocytosis of antigen. by B cells isotype switching somatic hypermutation Naive B cell activation by CD4+ TFH cells affinity maturation Question 13 3 pts Which of the following occur in both B cells and T cells? alternative splicing to produce a secreted form of the receptor isotype switching O alternative splicing to produce different isoforms of the receptor somatic hypermutation somatic recombination

Answer 1

* Naive B cell activation by CD4 + TFH cells.
Germinal centers are sites within lymph nodes and spleen where the B cells proliferate, differentiate and mutate their antibodies by process called somatic hypermutation. B cells of the germinal centers are called centroblasts. Germinated centers are responsible for the production of affinity matured B cells. In the process of promoting germinal center the antigen phagocytosis is achieved by the B cells which is driven by BCR and dependent on the GTPase. It is important for the development of antibodies. The germinal center is considered as the major location for the isotype switching where the B cell indicate the switching of DNA circles.

13. Somatic recombination.
Somatic Recombination is the process where the functional genes for the immunoglobulin and receptor chains are assembled. the lymphoid proteins regulate this recombination process both in T cells and B cells.