Question

Which of the following is incorrectly matched?

		MHC-II ; alpha 1,2 and beta 1,2 domains
		MHC-II ; present on all body cells
		MHC-I ; antigen binding site is composed of alpha 1 and alpha 2 domains
		MHC-II ; presents extracellular antigens from pathogens or other non-self proteins
		MHC-I ; presents intracellular antigens from viruses or degraded self-proteins
		MHC-I ; presents antigen to cytotoxic T cells
		MHC-I ;  alpha 1,2,3 domains and beta macroglobulin
		MHC-II ; presents antigen to T helper cells

The T cell receptor and B cell receptor differ from one another in all of the following ways EXCEPT:

		somatic hypermutation after activation
		number of antigen binding sites
		somatic recombination before maturation
		number of constant and variable regions

Which of the following is matched INCORRECTLY?

		Genetic polymorphism Many different alleles for a certain trait that exist within a population
		Isotypes Different proteins that are produced by the different genes from a gene family
		Alleles The different variants of a gene
		Polymorphic There are many different alleles for one gene within a population
		Monomorphic There is only one allele for a gene within a population
		MHC class I isotypes: HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, and HLA-G
		MHC class II isotypes: HLA-DM, HLA-DO, HLA-DP, HLA-DQ, and HLA-DR
		Haplotype The complete complement of MHC-I and MHC-II genes that an individual inherits from both of their parents

Answer 1

Given in the question

Which of the following is incorrectly matched?

		MHC-II ; alpha 1,2 and beta 1,2 domains Option 1
		MHC-II ; present on all body cells. Option 2
		MHC-I ; antigen binding site is composed of alpha 1 and alpha 2 domains. Option 3
		MHC-II ; presents extracellular antigens from pathogens or other non-self proteins. Option 4
		MHC-I ; presents intracellular antigens from viruses or degraded self-proteins. Option 5
		MHC-I ; presents antigen to cytotoxic T cells. . Option 6
		MHC-I ;  alpha 1,2,3 domains and beta macroglobulin. Option 7
		MHC-II ; presents antigen to T helper cells. Option 8

I have marked each of the option with Number

To answer lets understand MHC molecules

lutchouc # MAJOR Histocompatibility Complex Molecelles (Mic class I & MHC class I) Host upous Graft rejection reachen in tissue transplantachon Genes present on - mic locas CALLA) HLA- Human leukocytes Antigen. Graft transplant host Nk cells & Tcytotoxic cell Non peu'fic recognisalon Rejection of Craft In mice - Mic molecule Expressed on cell

Mayor Histoceny etibility complex LRat - 17 chome Human = der-6 3 dift syne M MHC cleiss ] Z (2) MHC class II I 3) MHC clas I Transmembrane pot. Antigen presentation Secreted pot. Cytokines. TNF 4/B o inflammahon signed In Human - TILA - Human leukocyte Antigen

MHC class I HLA A HLAB, ULA-C MHC class I HLA-Bp Hen-DO, HLA-DR Structure of MHC class I e Teylon a=48Kck / peptidke Bindung greg 11 a.a pepho] Variable & Peripheral pole Constant "(- ß2 microglobulin fron-covalero interachanda B-12 Kda sbucwe Pobunan with, MHC class I molocale All nucleated cell Express CD&T - coreceptes of Recongnize ( Tcytotoxic cell doman 21 Mic class Expression I molecule. of Antigen presenting cells to Dendritic cell HBump uѕuал A maurophages

Peptide binding genre (10-20 capephoto Variable &, & B domain que transmembran 2=35k) B=28kda Constant MHC class II Helper Express Antigen presenting cells. Express Theeper cells = CD con receptes Recongenize B2) region Antigen MHC Cleess I Antigen mne class I - Expression - All nucleated ween tht to Icytotoxic cells bracellular bacteria virus infected Tuner Antigons Processed in tell Processing of thingen Cell than Jutra cellula Ege Cell cytoplasm tnt on MHC class I nolecul

Nucleus stras Trausporte, AA Viral Ocelen peph Crenome TAP pe Viral pot Dial pephile Viral prt. Ubiquitinization loaded on сис с to I molecul DG ERRE viral pephan TAP VA ogges Proteosome м/с Croust LED Viral pot transport into Cytosol Class Newly synsness , class I NHC Endoplamu reticulun Phogventosis or Endocytosis

Phagolysusis & Endocytosis Endoplama reticulun TER Teutoloxic е, мис touІ To Cell Killey of nost cell golgi Rotan hembrane

2) Muc class I to processing ocessing of the of Antigen Extracellular Bacteria, virus, parasite at • Phagocytosis & processing of Antigen . Adhigen tnt to I Helpes cell c a rne Baptiste m cleaugos A MA-DHI cheun cleance Baclenal peptid lysosomu Kyocelluc Patogen Excortic vesille Mesicle evolgi Thay olysosone Endosome speap (CLIP) Synthess of 17 Invarient chain bind to mic wot mo MHC class I Molecule afw vesicle Vesicle

oor APC tun COYO COMO CO MHC class II To activated release cytokines heneba
Hence in the above question all option are correctly matched except option 2 MHC -l is present in all body cell not MHC-ll

MHC -ll is present in antigen presenting cell dendritic cell, B lymphocytes, macrophages

Hence option 2 is correct answer

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