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Explain why/how human cells are highly resistant to immortalization and transformation in comparison with mice cells.

Explain why/how human cells are highly resistant to immortalization and transformation in comparison with mice cells.

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One main feature of cancer cells is its ability to replicate at a high speed without stop. This is called as immortialization.
Humans are known to have have resistance to immortalization . It is due to their genetic constitution .
Compared to mice,they have higher resistance to immortalization.
This can be becuase of their low DNA repair, poor genetic stability etc
Even though both humans and mice undergo
senescence of their primary cells,the humans have an enzyme called as telomerase that helps maintain the length of the telomeres and integrity of the cell membrane.
Its found out that in mice, this enzyme leaks out leading to neural and disfunctioning of other tissues,
Therefore,it nullifies their resistance to immortalization.

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