Question

ALL THE ANSWERS PLEASE!

Pretend you have a disagreement with a surly lab partner some day, and as a result of the fray, you have received a scalpel cut to the arm. Your arm rapidly becomes inflamed, and after the course of many days, an infection develops. Luckily, the infection later clears up. Assuming the pathogen responsible was never previously encountered by your immune system, which sequence of events below best fits with what could have happened (not all of the possible immune reactions are included in the lists)?

Question 1 options:

	A) 1. Alternative complement pathway activation 2. B-cell activation  3. Neutrophil activation
	B) 1. Neutrophil activation 2. B-cell activation    3. Alternative complement pathway activation
	C) 1. Release of C reactive protein from the liver 2. Alternative complement pathway activation   3. Neutrophil activation
	D) 1. Alternative complement pathway activation  2. Neutrophil activation  3. B-cell activation

Question 2 (2 points)

The membrane attack complex (MAC) is formed through

Question 2 options:

	A) B cell activation
	B) T cell activation
	C) complement activation
	D) neutrophil activation
	E) NK cell activation

Question 3 (2 points)

Which of the following events is most directly and immediately responsible for anaphalatoxin production?

Question 3 options:

	A) Complement activation
	B) Dendritic cell MHCII presentation
	C) Mast cell degranulation
	D) T-cell activation
	E) Type I hypersensitivities

Question 4 (2 points)

MHC class II binds primarily to which subclass of T cell

Question 4 options:

	A) CD2 positive
	B) CD3 positive
	C) CD4 positive
	D) CD8 positive
	E) none of the above

Question 5 (2 points)

Which is the most appropriate sequence of events in B cell signaling?

Question 5 options:

	A) Antigen binds BCR, intracellular receptor kinases (such as Fyn, Lyn or Blk) are activated, Syk is recruited to ITAMs on Igα/Igβ.
	B) Antigen binds BCR, Syk is recruited to ITAMs on Igα/Igβ. intracellular receptor kinases (such as Fyn, Lyn or Blk ) are activated,
	C) Syk becomes activated, the BCR can now bind an antigen, and intracellular kinases are activated.
	D) Intracellular receptor kinases (i.e. JAKs) are activated, antigen can now bind to the BCR, Syk is recruited to ITAMs on Igα/Igβ.

Question 6 (2 points)

Follicular dendritic cells are somewhat specialized antigen presentation cells and are found primarily:

Question 6 options:

	A) in the peripheral blood
	B) in the primary lymphoid organs
	C) in the secondary lymphoid organs
	D) in synovial fluids
	E) none of the above

Question 7 (2 points)

Of the following, which should NOT occur in order to facilitate T-cell selection in the thymus?

Question 7 options:

	A) positive-selection based on an interaction with MHC alone
	B) negative-selection based on a failed interaction with self-peptides in a MHC
	C) apoptosis of T-cells that fail to interact with MHC alone during positive selection.
	D) negative-selection based on an interaction with MHC containing a non-self peptide

Question 8 (2 points)

CTLs use the following membrane-bound protein interactions to “kill” a target cell through apoptosis:

Question 8 options:

	A) IL-2/IL-2 receptor
	B) CD4/MHC II
	C) TCR/MHC II
	D) Fas/FasL

Question 9 (2 points)

Which of the following is NOT a professional antigen presenting cell (i.e. doesn’t express MHCII)?

Question 9 options:

	A) neutrophil
	B) B cell
	C) dendritic cell
	D) macrophage
	E) all of the above are professional antigen presenting cells

Question 10 (2 points)

Which of the following describes a cytokine that typically cause a leukocyte to undergo extravasation (also called diapedesis or transendothelial migration)?  

Question 10 options:

	A) allergens
	B) haptens
	C) chemokines
	D) complement

Answer 1

Alternative complement pathway is Part of innate Immune vesponse that is activated in vresponse to the Pathogen attack.

Neutrophil cells are first oresponder that eliminate attack the This cause inflammation any foreign material that can cut site B cell activation As þathogen is not pereviously attack to clear it B cells are activated against it.

Option d correct. 2) Obtion C correct Complement activation cause the formation og memberane memboyane attack complex. 3. complement activation 4. CD4 Positive