Question

i need help with this mexhanism please

CH(CH.CH,CH e CHCH,OH, H CF3CO,H © CH:CH,OH, [(CH3),COCO,0 DCC Na,CO3, H,0 HCI [(CH3),COCO],0 CHECH) edit structure ... edit structure... DCC [(CH3),COCO), NaCO3, H,0 CH,CH,OH,

Answer 1

solution: си и до СИН он К :В amine group This is protection of in Boc anhydride 3 4 Ho- Ć - By product- Заве - contan : 4 ҷо бо Ф. to- Hochph ~ Се - ои -Он " си (си) син, CH(CH3) CH₂ CH3 и о он ко, HN- он Ф си, Р, 15 см (с осH, Ph " си (cm) си с ) си, с о. дзе the - Нао 2" no- CH₂ Ph и cinchl си (си) си си, " сн(ско) си. Сиз

This is a acid catuly sed estar formation -R R-N=c=N R - N =c=N-R o tte Boc N - BOCN R = I J c yclohexyl group) H NOR NO Bon BocN → Boc N T - u=- HN LocHaph "* CH(CH3) (H CHz и че BON Во т и си, Ph 7" cң сия) си, си, 0 M A R-N -e- 21 BocN IZ on. CN och ph HH "CH (CH3) CHh Rth Dicyclohexyl usea This is acid into amide coupling good leaving group up Reaction of follould by fallowed by acid with occ, it convert amine amine attack attal to give amide

CF3 cool UM ®, но он CIK och ph и с си, с, т, о си ? Н BocN Вост си (с но) са си, И. Н Н%9 TH со си DOCN 2x x BocN R: си ссн; ) с ск, W, Но - Он BOCN Іг "12 PhcH2-OH - Вис о м тик, сн (cm) cң си cataly sed The is acid and estar ester acid alcohol hydrolysis to give