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WEEK 6: ANALYZING A CASE STUDY WBC 8.3 x 109/L Segmented Neutrophils 32% Band Neutrophils 0%...

WEEK 6: ANALYZING A CASE STUDY

WBC

8.3 x 109/L

Segmented Neutrophils

32%

Band Neutrophils

0%

Lymphocytes

60%

Monocytes

6%

Eosinophils

2%

Basophils

0%

RBC

4.20 x 1012/L

Hgb

13.1 g/dL

Hct

40%

RDW

11.8%

Plt

226 x 109/L

Morphology

Unremarkable

  

PT

13.2 sec

APTT

33 sec

Bleeding Time

16 min

Platelet Aggregation

No response to ADP, collagen, thrombin, and epinephrine  

In your discussion post, answer the following questions regarding the results: Based upon the patient’s lab results, what diagnosis would be determined? What would the platelet aggregation response be to ristocetin?

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Answer #1

1. Based on the lab results, all the lab values are normal except for bleeding time. The normal bleeding time is 2-9 minutes.

This shows the patient have a bleeding disorder, most probably Von Willebrand disease. Von willebrand disease is caused by deficiency or defect of Von Willebrand factor. It causes excessive bleeding and increased bleeding tendency.

Ristocetin is an antibiotic used for the detection of von Willebrand disease and Bernard Soulier syndrome.

In normal blood when ristocetin is added it results in agglutination of fixed platelets. In case of VonWillbrand disease agglutination will either be hypoactive or hyperactive.

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