2. Why do researchers state that randomized clinical trials provide the strongest evidence for an individual study when using an evidence-based model?
Randomized clinical trials provide the strongest evidence for an individual study when using an evidence-based model as they negate the effect of the confounding factors. Further, it is; conceptually easier to attribute any observed effect to the treatments being compared in a randomized clinical trial.
2. Why do researchers state that randomized clinical trials provide the strongest evidence for an individual...
7. Ethical standards for randomized, controlled clinical trials include never testing drugs which have not been proven to be completely safe. not asking subjects to agree to participate without first informing them of the nature of the study and possible risks and benefits. ensuring that each subject knows which treatment he or she received. allowing subjects to decide whether or not to be in the control group. all of these. 8. Which of the following is not a requirement for...
Researchers conducted a randomized, double-blind clinical trial to compare the herb St. John's Select one wet Wort, the antidepressant drug sertraline, and a placebo for the treatment of depression of the 10 points 113 patients in the herb treatment group, 23.9% showed improvement, compared to 24.8% of the 113 in the sertraline group and 31.9% of the 113 patients in the placebo group. Medscape Medical Newspublished this research in 2002. Is a normal model a good fit for the sampling...
In randomized, double-blind clinical trials of a new vaccine, rats were randomly divided into two groups. Subjects in group 1 received the new vaccine while subjects in group 2 received a control vaccine. After the second dose, 124 of 558 subjects in the experimental group (group 1) experienced fever as a side effect. After the second dose, 90 of 593 of the subjects in the control group (group 2) experienced fever as a side effect. Does the evidence suggest that...
In randomized, double-blind clinical trials of a new vaccine,rats were randomly divided into two groups. Subjects in group 1 received the new vaccine while subjects in group 2 received a control vaccine. After the second dose,126 of 394 subjects in the experimental group (group 1) experienced drowsiness as a side effect. After the second dose, 170 of 620 of the subjects in the control group (group 2) experienced drowsiness as a side effect. Does the evidence suggest that a higher...
8. Researchers investigated the issue of race and equality of access to clinical trials. The table given in (a) shows the population distribution and the numbers of participants in clinical trials involving lung cancer At a significance level of 0.01, using a P-value test, test the claim that the distribution of clinical trial participants fits well with the population distribution. Is there a race/ethnic group that appears to be very underrepresented? Use the following steps: (a) Complete the expected column...
7. Do diet sodas contribute to obesity? Researchers recruited 1,200 randomly selected college students at state universities in Texas to participate in a four- year study looking at the relationship between diet soda and obesity. At the start of the study, students were weighed and interviewed. After interviews w the students, participants were classified as either regular soda drinkers, diet soda drinkers, or non-soda drinkers. Four years after the interview, the students were contacted again and reweighed. The weight gains...
In randomized, double-blind clinical trials of a new vaccine, monkeys were randomly divided into two groups. Subjects in group 1 received the new vaccine while subjects in group 2 received a control vaccine. After the second dose, 128 of 695 subjects in the experimental group (group 1) experienced drowsiness as a side effect. After the second dose, 85 of 576 of the subjects in the control group (group 2) experienced drowsiness as a side effect. Does the evidence suggest that...
5. In randomized, double-blind clinical trials of a new vaccine, children were randomly divided into two groups. Subjects in group 1 received the new vaccine while subjects in group 2 received a control vaccine After the second dose, 115 of 485 subjects in the experimental group (group 1) experienced fever as a side effect. After the second dose, 106 of 574 of the subjects in the control group (group 2) experienced fever as a side effect. Does the evidence suggest...
1. When conducting a randomized clinical trial, participants are recruited and told about the study. 2. What is the critical step that must be taken prior to conducting any research procedures
ANSWER THE FOLLOWING QUESTION 1. Provide a brief description of the structural components required for a clinical trial. These include: subject selection/recruitment, power and sample size, randomization, blinding, compliance, analysis. (10 pts.) 2. What was the rationale for the study? (no more than 3 sentences) (5) 3. What was the primary result of the study? (no more than 3 sentences) (5) 4. Comment on the validity of the study. (5) 5. Why is the randomized clinical trial near the top...