Question

5. Rank the following in decreasing nucleophile quality (1=strongest)? How many are considered strong nucleophiles? (3pts) We will no lo 6. Do you think it is both a strong nucleophile and a strong base? Why or why not? (2pts) Li

Answer 1

The answer is given in the attachment.
nucliophile can donates its e-pair to a no La elechobhile.. When there is negetive charge ie there is much more electron density that reanike.easily desiated... Another point is electronegetirity. As the electronegetirity increases that will be less willing to doncistes electron. Another point is resonance, when in : Cais boscylate in the are charge is delocalised btn atoms , them election density to a particular position is decreasing Eletro megetirity of myzen) mitozen. so n ou will be more nucleophile than t o them comes not Cars uncharged) and them ao . (election density is de localized) Cherefore the nucleophe licity order

: : Weakest. v > not shots vio frank) > > 3 5 strongest All of them are bulky in nature, in sige, so they can face huddets in approaching to the electrophile. So none of them are that much strong nucliophile CS Scanned with CamScanner

T amide) (LDA) It is a strong base but it is a . sion-nucleof hilic base a On the nitrogen there is negetive change in there is charge densites , it can easily be donated to a proton, so it is a resy strong bise. But LDA is very much bulky in nature size), so it can not approach to a de efrophilic Centre fie it does not give micheophile : - substitution with albyl halide and tosylates) so it is mosi- sucheophilic in nature. CS Scanned with CamScanner