R2Culi react to yield 1,4 adducts (Thermodynamic) [1] R'Culi [2] H20 R VB R' [1] (CH3)2Culi...
li NaOH, H20 heat 1. (CH3)2Culi, ether 2. H30* H 3 4
RLi and RMgX yield 1,2- adducts (Kinetic) [1] R'MgX or R'Li ОН 0 k [2] H₂O RI R' allylic alcohol [2] H20
W... is the major product of the following reaction? 1) (CH3)2Culi 7 2) H2O ОН O
colecta NaOH H + CH3 then heat NaOH tir then heat NaOH (CH3)2Culi then heat 1. NaOCH3 CH3OH OCH3 2. dil. HCI O 1. LDA 1. LIAIHA het hy 2. Br 2. H2O* 1. NaOCH3 1. NaOCH3 2. CI OCH; 2. Ph Br 3. H3O+, heat 1. LDA 1. LDA 요 2. 0 CI 3. H3O+ 2. H 3. H30+
OH 1. NaOCHZ 2. H20 CO2H acid catalyst hint: - BuOH 1 2 NaOH, H2O heat 1. (CH3)2CuLi, ether 2. H30* H 3 1. NaOCH3 u 1. H307 2. heat 2. Br Br 5 6
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JUST DRAW ARROWS...
(CH3)2Culi + CH3Cu Ph CI Ph CH3 The ketone intermediate formed in the reaction of an acid chloride with a Grignard reagent cannot be isolated because it reacts too rapidly with the second equivalent of Grignard reagent. To produce a ketone from an acid chloride, one can treat the acid chloride with a lithium dialkylcopper reagent. The reaction occurs by nucleophilic acyl substitution on the acid chloride by the dialkylcopper anion to yield an acyl...
1. CH MgBr 2. HO 1. (CH3),Cuti 2. H2O 1. CHg MgBr 2. H20 1. (CH3)2NH 2. H20 2. H20 1. CH CHANH, OCH,CHE 2 HO CH OH • Sul
Identify the starting material for the following transformation. 1) (CH3CH2)2Culi 2) H20 - hotely hoy at gays B)
QUESTION 3 What is the major organic product obtained from the following reaction? 1. (CH3)2Culi a ОН 2. H20 H N a. 1 b.2 C. 3 d.4 QUESTION 4 What is the major organic product obtained from the following reaction? OH OH 1.2 eq. CH3MOCI OCH, 2. H30* осн, a. 1 b.2 C. 3 d.4
Which set of conditions will achieve the transformation shown? 1. LIAIH4; 2. H /H20; 3. (CH3)2CHNH2 (exCess) 1. LIAIH4; 2. H*/H2O; 3. NaBr; 4. (CH3)2CHNH2 (excess) 1. CH3MgI; 2. H*/H2O; 3. (CH3)2CHNH2 (excess) 1. CH3M9I; 2. H*/H20; 3. TosCl; 4. (CH3)2CHNH2 (excess) 1. (CH3)2CHNH2; 2. LIAIH4; 3. H20