Question

le glucose Suusti dle! 6. The Vmax and KM values for an unusual hexokinase found in Trypansoma cruzi (the causative agent of Chagas disease) are shown in the presence and absence of a bisphonate inhibitor (structure shown). Without inhibitor With inhibitor KM (MM) Vmax (umol. min . mL-1) 90 0.30 125 0.12

Answer 1

line-weaver Beste plots for Enzyme on Libiten Inlibile no In Lebar Compete the Inhibition KH increen Vina unakker Uncompetecture InLibition km & diled max reduled without I 90 Non compekti amned) Intiblog KH unafucked un xduad with I 125 is created 0012 decrears Given KM CM) Ugnen 0.30 Inhibition This is mixed

6 parasix heaolinase e is hebind ss PPÈ See not Glucose-6-phosphate & It is consisten te witha, sule, it seems intibition requirs two phosphate group lincued by 1 atom . C g t is a good candidate; since it betto con act on E or ESs here it is acting on the afore Inhibits E is itself, any action on substrate will not take place (reduced effectuely-