Question

14. What does the term "prognosis" refers to? What is the current prognosis for patients with untreatable glioma multforme? What imaging modalities are used to help diagnose this disease? What are therapeutic options for this disease? 15. Case Study Question: Ms. Smith has a kidney disease with moderate renal insufficiency When administering a nuclear pharmaceutical that requires clearance via the kidney, what precautions and considerations should you make if you must perform a scan using a nuclear pharmaccutical that requires a renal clearance determination for Ms Smith? What pharmacokinetic parameters will you take into consideration and why?

Answer 1

14. Prognosis is a medical term which defines or predicts the likely course of a medical condition .

The prognosis for a untreatable glioma multiform is poor prognosis as it's reflected from the name itself untreatable glioma multiform and also glioma is one of the most dangerous form of brain tumor .

# The imaging modalities used to diagnose glioma are:-

- MRI( mostly used )

- CT scan

- PET scan

# Treatment options of the disease are :-

- Steroids to reduce inflammation

- Anti epileptics for preventing seizures

- Radiation therapy

- Chemotherapy

- Targeted drug therapy

- Surgery

15. Here in this case Mr Smith has moderate( GFR>30) renal insufficiency . GFR more than 30 is safe to give a regular contrast material .

The pharmacokinetic parameters that will be considered are clearance , VOD ,AUC ,Cmax Half time because Mr. Smith has renal insufficiency it will take time for the kidneys to flush out the dye hence clearance will be slow and will increase other parameters .