Conditions Starting Material Major Product(s) OH PBrg Et20 NaCN DMF OMs NaNH2 DMSO, 20'C 8 hr...
Starting Material Conditions OH PBr3 Eto C NaCN OMs DMF Br NaNH DMSO, 20°C 8 hr 1) NaH, DMF, -78°C 2) A ci NaOH
• Please provide the major organic product(s) of the reaction as described Account for all stereochemistry requirements for reaction and products. You need not include byproducts such as salts for this assignment, but you should be aware of their presence. "No reaction is NOT a possibility on this assignment Starting Material Conditions Major Product(s) ОН PBr3 Et20 NaCN DMF NaNH2 DMSO, 20'C 8 hr 1) NaH, DMF, -78°C 2) M ai NaOH
• Please provide the major organic product(s) of the reaction as described. Account for all stereochemistry requirements for reaction and products. You need not include byproducts such as salts for this assignment, but you should be aware of their presence. "No reaction" is NOT a possibility on this assignment. Starting Material Conditions Major Product(s) ОН PB13 Et20 NaCN OMs DMF Br NaNH2 DMSO, 20'C 8 hr
Please provide the major organic product(s) of the reaction as described. Account for all stereochemistry requirements for reaction and products. 1) NaH, DMF, -78 C d) CI 2) NaOH e) Br OH 1
1. Predict the product(s) (or no reaction) and reagent(s). j. ETOH Br heat k. Br NaOH DMSO NaCN Br DMF m. РСС Н n. О H2SO4, H20 Н
draw major product CHCI 1) KOH/DMF HANNH, EIOH NaN, LAH THF NaCN LAH THF DMSO HONO, Hy/Ni CH,OH H2SO4 1) SOCI, /py LAH Hy/Ni CH,OH H. (cat) -H₂O NaBH,CN CH, OH
For the questions below, provide the missing portion (product, starting material or reagents/conditions): OH CH3Br HO O NaH, DMF OH HO OBn 100% B- anomer (benzyl removal)
1. Predict the major substitution product(s) for the following reactions. Include stereochemistry if appropriate. You may assume an aqueous workup is performed after each reaction. 1. Nah, DMF ТОН 2. Mel BrMg-Ph KCN 16 { ad ton ot MeOH HD Na Br Me DMSO EtOH Br ~ Br DMSO * Me OH LNH2 M HO Me-S (1 equiv) Me DMF
1. Provide the missing starting material, reagents, or major organic product for each of the following reactions. (No more than two steps are required in any case where we ask you to fill in reagents.) 1. Mgo, Et20 2. H20 a) Cl b) MgBr OH , Et20 2. H* workup c) OH d) NaOH (cat.) e) OH NaBH4, CeCl3, MeOH
13) What would be the major product(s) of the following reaction? NaCN I DMSO DMSO Llar Loo A ho г A)I п B) 1 ш C) III DMSO у D) IV E) None of these choices.