Question

4. Determine if the following commercial products are hypotonic, isotonic, or hypertonic: 0 1 L of a parenteral solution containing 20% w/v of mannitol (NaCleq = 0.18) o Fleets saline enema Contains: 19 grams of monobasic sodium phosphate (NaCleq = 0.49) 7 grams of dibasic sodium phosphate*7H20 (NaCleq = 0.29) in 120 mL of purified water solution ► What is the approximate pH of Fleets saline enema? Common Buffers Phosphate Buffer pka 6.8 Molecular Weight of Acid 120 g/mol Molecular Weight of Base 268 g/mol

Answer 1

Question 4.

(i) The weight of mannitol = 20 g/100 mL * 1000 mL = 200 g

The NaCl equilvent of mannitol = 200 g * 0.18 = 36 g

The actual amount of NaCl required = 0.9 g/100 mL * 1000 mL = 9 g

Here, the amount of mannitol (36 g) > required amount of NaCl (9 g), hence it is hypertonic.

(ii) The NaCl equivalent of monobasic sodium phosphate = 19 g * 0.49 = 9.31 g

The NaCl equivalent of dibasic sodium phosphate.7H2O = 7 g * 0.29 = 2.03 g

The total mass = 9.31 + 2.03 = 11.34 g

The actual amount of NaCl required = 0.9 g/100 mL * 120 mL = 1.08 g

Here also, the the amount of mixture of phosphates (11.34 g) > required amount of NaCl (1.08 g), hence it is hypertonic.