There are widely used methods for synthesis of Alkyl bromide
SN1 Reaction (Substitution of nucleophile uni molecule)
SN2 Reaction (substitution of nucleophilic bi-molecule)----Williamson ether synthesis
Experiment 4: Synthesis of a tertiary alkyl halide Page 3 of 6 The term "side reactions"...
Experiment 4: Synthesis of a tertiary alkyl halide Page 5 of 6 Experiment 4: Synthesis of a tertiary alkyl halide Page 5 of 6 Assuming that all other experimental conditions are the same; explain if an S,1 reaction would still occur if the following changes were made. If an Sk1 reaction would still occur: then state the IUPAC name and draw the structure of the product formed compare the rate of reaction to the rate of the original reaction (in...
The term "side reactions" refers to any chemical reaction that can occur that form products other than the desired product. Side reactions can consume the reactants of your intended reaction, and can affect the percent yield of your target product. One possible side reaction produces butyl ethyl ether. Draw the complete reaction mechanism for the formation of butyl ethyl ether as a side product 2 Marks]
Experiment 4: Synthesis of a tertiary alkyl halide Page 3 of 6 Distillation is a technique that is to purify liquid compounds. Use theoretical data to explain how distillation is used to separate the target product in this reaction from any residual unreacted starting material in the reaction. [2 marks]
Experiment 4: Synthesis of a tertiary alkyl halide Page 4 of 6 Why do we wash the organic layer with saturated NaHCO3(aq)? Include a balanced chemical equation illustrating the chemical reaction that is occurring as part of your answer. (1 Mark) Scenario: While working in an organic lab, you have been asked to prepare 5.0 g of 2,5-dichloro-2,5- dimethylhexane from 2,5-dimethyl-2,5-hexanediol. Draw the complete mechanism for the reaction. [2 Marks] When setting up the reaction above, is your starting material...
13 SN1: Synthesis of tert-Butyl Chloride Alkyl halides can be prepared from their corresponding alcohols via an acid catalyzed substitution reaction. The mechanism of these acid catalyzed substitution reactions are labeled as Syl (substitution, nucleophilic, unimolecular) and S2 (substitution, nucleophilic, bimolecular). Tertiary alcohols follow the Snl route, primary alcohols follow the S2 route, and secondary alcohols can follow either path. Under acidic conditions, the mechanism (Figure 1) of the Sul reaction involves rapid protonation of the alcohol, followed by the...
Experiment 14 SN2: Synthesis of 1-Bromobutane Alkyl halides can be prepared from their corresponding alcohols via an acid catalyzed substitution reaction. The mechanism of these acid catalyzed substitution reactions are labeled as SNI (substitution, nucleophilie, unimolecular) and S2 (substitution, nucleophilie, bimolecular). Tertiary alcohols follow the Syl route, primary alcohols follow the S2, route and secondary alcohols can follow either path. Sth CyHe 81 CH? Br-CH e-OH- -C-OH OH Figure / Conversion of 1-butanol into 1-bromobutane by an Sp2 mechanism The...
HO Regarding the following reaction: 1) a. Classify the alkyl halide as tertiary, secondary, or primary. b. Based on your answers to la, deduce whether the alkyl halide would be suitable for (i) only S2 reactions, (ii) only Ss 1 reactions, or (1) both/either S2 or S1 reactions. 2) a. Classify the nucleophile (the electron-sharer) as either strong or weak b. Based on your answer to 2a, deduce whether the nucleophile would be suitable for (i) only Sw2 reactions, (1)...
for the reaction: acetaminophen + (NaOH/EtOH note: etoh is ethanol) and butyl iodide ---------------> 4-butoxyacetanilide a) The first step in this reaction is to reflux acetaminophen in a NaOH/EtOH solution, followed by the addition of butyl iodide. What is the purpose of using the NaOH/EtOH solution? Would the SN2 reaction still occur if the first step was not completed? Why or why not? b) Upon completion of the reaction (before filtration), an additional 4.0 mL of 1.0 M NaOH/EtOH was...
13 SN1: Synthesis of tert-Butyl Chloride Alkyl halides can be prepared from their corresponding alcohols via an acid catalyzed substitution reaction. The mechanism of these acid catalyzed substitution reactions are labeled as Syl (substitution, nucleophilic, unimolecular) and S2 (substitution, nucleophilic, bimolecular). Tertiary alcohols follow the Snl route, primary alcohols follow the S2 route, and secondary alcohols can follow either path. Under acidic conditions, the mechanism (Figure 1) of the Sul reaction involves rapid protonation of the alcohol, followed by the...
The reaction is: 2-methyl-2-butanol + HCl --> 2-chloro-2-methylbutane via an SN1 reaction. Experiment 4: Synthesis of a tertiary alkyl halide Page 3 of 6 Distillation is a technique that is to purify liquid compounds. Use theoretical data to explain how distillation is used to separate the target product in this reaction from any residual unreacted starting material in the reaction. [2 marks]