Question

CONCEPT QUESTIONS Mechanism. While the reaction carried out in lab used potassium hydroxide as the catalyst, many other catalysts have been developed to increase regioselectivity and stereoselectivity in aldol condensations. One small molecule catalyst commonly used is proline, a naturally occurring amino acid. The mechanism involves the initial formation of an enamine; predict the structure of this enamine intermediate intermediate A), and draw the mechanism for the conversion of intermediate A to intermediate B. Helpful Hint: The formation of the new carbon-carbon bond occurs at the same time as protonation to form the alcohol. b. Draw the mechanism for the hydrolysis of intermediate B to form the final product and regenerate the catalyst. (0.2-0.3 eq.) R H DMSO-H2O intermediate A intermediate B Retrosynthesis. Identify the starting materials needed to make the following compound via an aldol condensation. ola =

Answer 1

N R$ HO was do [B] o r Internet Ketamin Enaminem tautomerism TL H2O Blů [produet) NO2 Forward reaction: us no OH OH DACA2 OH