Question

A) Search one of the ester in Sci Finder Scholar to find these information; thyi formate a) find two-reaction conditions to generate the ester, 1) with OR leaving group 2) with Cl leaving group b) which one is better and why, (indicate the yields) c) Indicate electrophiles, nucleophiles and in those methods.

Answer 1

O Et H A. E thyl Formate two-reaCon conditions to qfve the aster fina eaving rup OF 2 ith process o generation oe erter goas the througn се Et OH OFt base Duing the esterification, the stabilijty of product de pend oT ho qs0a the goup attach car bon to tho new are at eaving with megative tetrahedrad Chatges OE Lavina aoup tne esterification prace ss ith Snoutd be,- ELOH Et 3 a g OEt R O C leaving roup tne asterifica ti6 rocess Ard With Should be E+0H 0 E+ H OE+ b) Which one is aeHer ard why , esterifica Hon ceachorag the siability these ho goos tne roduct de pends on TOup attach are at eavin with of leaving to tne te tTAhedral megative change an d ease gToup. Leavingaoup with 1owes pKa value is best Suited The leaving roup oR Strona mreactive pKan value =16 Ahere as a1e StI tawara ba se s and ts the deaying qroup 'ei' as e very fon Stable unreacŁi ve

the megative chaige. Lt's pRau tno Lcaving roup.OR happfly coarries value is , that Suitd Herce C S bE Her hocause lQaving Tma imuvn mo12acH ve The Yields stble due to so acad oases as Ze The Yields o'ORis o meactvity ^owards Leaving 4roup Р Кaн Lower pkaH value се Higner the stability C) Tndicate e1ectrophiles , T=¢ nucleophiles (Ethy torma te) OE t EAH Base -OEt e t30 H canbonyi can bon acepting elechvon aensit 1eg arzded as electro phile He1e from Ethyl aicohet/ethanol Etöh) dorate its electron Carbony carbon (which is atectO And densit towaids electrophiic n ratuie) ard nenLe muclesphile acts as