Describe the progression of atherosclerosis and its role in the etiology of a myocardial infraction.

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Describe the progression of atherosclerosis and its role in the etiology of a myocardial infraction.

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Answer 1

Answer #1

PROGRESSION OF ATHEROSCLEROSIS

Endothelial injury

*initial triggering event

* caused by mechanical trauma,immunological and chemical mechanism etc.

⬇️

Intimal smooth muscle cell proliferation

*proliferation of cells by nitric oxide and endothelin.

⬇️

Monocyte adhesion to the endothelium

*immune system responds to injury

* oxidize LDL and form specialized cells

* white blood cells deposit in artery wall

⬇️

platelet adhesion

*platelets adhere to the injury site.

⬇️

Factor release

* from activated platelets, macrophages,arterial wall.

⬇️

SMC proliferation and ECM production

*artery became inflamed

* extracellular matrix formation leads to narrowing of artery and causes decreased blood flow.

⬇️

Lipid accumulation

* accumulation of lipid containing macrophages forms fatty streaks.

* fibrofatty atheroma formation

Role of atherosclerosis in MI

Atherosclerotic plaque in the coronary artery will decrease the blood supply and oxygen delivery to the heart. This leads to ischemia of the myocardium. Finally leads to death of myocardial cells.

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Answer 2

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Describe the progression of atherosclerosis and its role in the etiology of a myocardial infraction.

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