Give the relative rates of reaction of the four carboxylic acid derivatives below with t-butylamine to...
[Review Topics) References Give the relative rates of reaction of methyl decanoate with the four reagents below to give a reduction product. NaBH Diisobutylaluminum hydride (DIBAH or DIBAL) in toluene at -78° LiAlH, in anhydrous ether Most reactive 2nd most reactive 3rd most reactive Least reactive Submit Answer Retry Entire Group 9 more group attempts remaining [Review Topics (References) Give the relative rates of reaction of the four carboxylic acid derivatives below with methylamine to give an N-methyl amide. НЫС...
Give the relative rates of reaction of isopropyl butyrate with the four reagents below to give an N-methylated amide. Give the relative rates of reaction of the four carboiylic acid derivatives below with methylamine to give an N-methyl amide. Give the relative rates of reaction of the four carboxylic acid derivatives below with excess ethanol and a trace of HCI to give an ethyl ester.
Chem 202, Fall 2019 Homework Packet 9 (Carboxylic Acid Derivatives) 2. Reactivity of Carboxylic Acid Derivatives a. Rank the following carboxylic acid derivatives in order from LEAST reactive to MOST reactive when they undergo nucleophilic acyl substitution reactions: — '— ' la do lan loons obe OCH3 b. Justify your answer thoroughly in words. Your explanation should include, if applicable, definitions and explanations that cover leaving group ability, conjugate acid strengths, pKa values, etc. 4. Amide Formation Mechanism: Draw the...
Which of the following carboxylic acid derivatives is the least reactive in a hydrolysis reaction? Amide Anhydride Ester Acid halide
Part A Rank the following carboxylic acid derivatives in order of decreasing reactivity. Rank from most to least reactive. To rank Items as equivalent, overlap them Reset Help walio ΝΗ: Most reactive Least reactive Submit Request Answer 2 A 31 If you wanted to directly synthesize the following molecule: NH which of these acid chloride derivatives could you potentially use as a starting material without converting it to another derivative first? Check all that apply. Submit Request Answer Provide Feedback
The reactivity of carboxylic acid derivatives depends on their leaving group. Rank the following molecules from most reactive (-best LG) to least reactive (worst LG). Input a ranking number in the box next to each structure (1-best LG). CH₃ id
The reactivity sequence of carboxylic acid derivatives (acyl halides, anhydrides, acids, esters, amides) changes with the substituent. Acyl chlorides are most reactive, amides are least reactive. 1) Explain in detail why the reactivity changes in that sequence, 2) Where do carboxylates fit in that sequence and why? How does that impact on the way carboxylic acid reactions need to run? 3) Where do thioesters, RC(-O)SMe and acyl phosphates, RC(-O)OPO2OR fit in that sequence. Explain your decision
The reactivity sequence of...
Amides are prepared from carboxylic acid derivatives. In the reaction shown below, what is the correct structure for the missing reactant? Cheryl CH3CH2C-CI + 2(?) - CH₃CHY & N-CH3 + by-product CH3CH2C-N-CH3 CH2CH3 main product H H-N-CH2CH3 (A) CH2CH3 H-N-CH3 (B) CH2CH3 H-N-CH2CH3 (C) CH3 H-N-CH3 (D) Select one: O (A) (B) (C) (D) None of these
Carboxylic Acids and their Derivatives.
1. For the reaction below, give a detailed mechanism for both an acid-catalyzed and base-catalyzed reaction. (2pts) + CH OH IN Acid Catalyzed Mechanism: Base-Catalyzed Mechanism: 2. How would you carry out the following syntheses. (4pts) CN
2) Figure 8.1 displays the reactivity/stability series of carboxylic acid derivatives. In the final step of the reaction sequence you will perform in lab, an amine is converted to an amide using acetic anhydride. Rationalize the relative stability of the four carboxylic acid derivatives shown below by considering the % contribution of each of the resonance structures shown. It may be helpful to use the B3LYP/6-316(d) NBO data provided below via QR codes and on Canvas. (4 pts) Нас H3C^x...