Question

Based on what you know about Fragile X syndrome so far, which of the following statements are true of a female who has one premutation allele of FMR1? (select two answers)

1. She may have affected children, but only if her partner also has a premutation allele.

2.She will not be affected if her other copy of FMR1 has a shorter repeat length.

3.She may or may not be affected with some of the phenotypes of Fragile X.

4. She may have affected children.

Explain please. Don't answer if youre not sure! don't pretend.

Answer 1

This a genetic disease where the cognition and the learning capabilities are affected.

The males are common affected than female.

Here it is a X linked dominant inherited pattern.In simple a female has two X chromosomes, when any one chromosome get a or inherits this dominant X link in it ,then definitely the diseases will occurs.They tend to pass it to their children both boy and a girl.Women with pre mutation FMR1on X chromosome is at greater risk of transferring it to her children.The female who has permutation career doesn't exhibit any clinical symptoms.They may or may not be affected ifother is normal X chromosome

But in case of male there are two chromosomes X and Y. Only when the dominant X link is inherited then the disease occurs and they pass only to their daughter and not to son.They develop strongly because tgere is only one X chromosome

Ans:She may have affected children

She will not be affected if the other copy of FMR1 has a shorter repeat length