Question

3. Order: Neupogen (filgrastim) 50 mcg/kg subcut daily The strength is 300 mcg 1 mL in a single-use vial. The patient weighs 39 kg. How many milliliters of this drug will you administer? 4. Order: Ticar (ticarcillin disodium) 1 g IM q6h The reconstitution directions on the 3 g vial state, "add 6 mL Sterile Water for Injection to the vial yielding a concentration of 385 mg/mL." How many milliliters of this antibiotic drug will you administer?

Answer 1

3. Ordered dose of filgrastim is 50mcg /kg

Available strength of filgrastim is 300mcg in 1ml in a single use vial

Weight of the patient is 39 kg

Dose for the patient is 50 mcg / kg = 50× 39 = 1950 mcg

300 mcg of filgrastim is present in 1ml

1 mcg of filgrastim will be present in 1 / 300

1950 mcg of filgrastim will be present in 1/ 300 × 1950 ml

= 6.5 ml

6.5 ml of filgrastim has to be given from the vial to administer a dose of 1950 mcg .

4. Ordered dose of Ticar is1gm IM q6 h

Available vial of Ticar is 3gm

Reconstitution direction on 3gm vial is to add 6 ml of sterile water for injection to the vial yielding a concentration of 385mg /ml .

1gm is equal to 1000mg

By adding 6 ml of sterile water to the vial ,it yields 385 mg in 1ml

385mg of Ticor is present in 1ml

1 mg of Ticket will be present in 1 / 385

1000mg of Ticket will be present in 1/ 385 × 1000

= 2.59 ml of diluted injection has to be administered to give a dose of 1gm Ticor.