Explain how the effects of sickle cell disease demonstrate that hemoblobin undergoes a conformational change upon...
Explain how the effects of sickle cell disease demonstrate that hemoblobin undergoes a conformational change upon releasing oxygen.
Homework Answers
Answer:
In hemoglobin S, the wild-type glutamate at residue 6 of the B-chain is replaced by valine. When oxygen is bound, both hemoglobin A and hemoglobin S are soluble, but in the deoxy-form. Hemoglobin S (but not hemoglobin A) becomes very insoluble due to exposure of hydrophobic valine residue. This exposed patch causes aggregation of deoxy-hemoglobin S into long insoluble fibrous aggregates, resulting in distorted shapes of the red blood cells and leading to the symptoms of the disease.
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Explain how the effects of sickle cell disease demonstrate that
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According to the Centers for Disease Control and Prevention (2017), approximately 100,000 Americans have sickle cell...
According to the Centers for Disease Control and Prevention (2017), approximately 100,000 Americans have sickle cell disease. Red blood cells that contain sickle hemoglobin are inflexible. This results in the cells adhering to blood vessel walls which slows or stops blood flow. This diminished or absent flow limits the amount of oxygen reaching cells and leads to attacks of sudden pain or crisis. Many clients with sickle cell disease also experience chronic pain. Hulihan, M., Hassell, K., Raphael, J., Smith-Whitely,...
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