Use the following information to answer the next two questions. Sickle cell anemia is a disease...
Use the following information to answer the next two
questions.
Sickle cell anemia is a disease that is caused by a mutation in the
gene that produces haemoglobin. Hemoglobin carries oxygen in red
blood cells. The HbA allele produces normal hemoglobin and the HbS
allele produces haemoglobin that sticks together and causes red
blood cells to sickle. Heterozygous individuals (HbAHbS) produce
both normal and "sickle" hemoglobin so the HbA and HbS alleles are
codominant. Heterozygotes do not develop sickle cell anaemia and
are described as having the sickle cell trait. Individuals that are
homozygous for the sickle allele (HbSHbS) only produce "sickle"
hemoglobin and develop sickle cell disease.
Note: Individuals that have sickle cell trait and sickle cell
disease have protection against malaria so the HbS allele is higher
in areas where malaria is common.
A man who is homozygous for the normal allele married a woman with the sickle cell trait. What is the expected probability of this couple having a boy with the sickle cell trait?
Homework Answers
To summarize, HbA:Normal
HbS: Sickle cell
Thus, homozygous HbA/HbA will be normal; HbA/HbS (heterozygous) will have sickle cell trait and HbS/HbS (hmomzygous) will have sickle cell disease (note the difference between sickle cell trait and sickle cell disease.
Man is homozygous (HbA/HbA) and woman has sickle cell trait which means she is heterozygous, HbA/HbS. Following will be the cross
| HbA | HbA | |
| HbA | HbA/HbA (Normal) | HbA/HbA (Normal) |
| HbS | HbA/HbS (Sickle Cell trait) | HbA/HbS (Sickle Cell trait) |
Thus 50% of the offspring will suffer from sickle cell trait.
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Use the following information to answer the next two
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Sickle cell anemia is a disease...
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Q5.1. Which of the following is FALSE? If a genetic disease reduces fertility and the allele that causes the disease offers no other advantage, the allele will likely eventually disappear, due to natural selection. Natural selection does not favor individuals who are homozygous for the sickle- cell allele, because these individuals typically die before they are old enough to reproduce. Individuals who are heterozygous HbA/HbS are protected from malaria, and this is why sickle-cell disease persists in wetter, mosquito-prone regions...
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JUST PART B PLEASE AND THANK YOU TABLE OF CHI SQUARED VALUES. D.F = DEGREES OF...
JUST PART B PLEASE AND THANK YOU
TABLE OF CHI SQUARED VALUES. D.F = DEGREES OF FREEDOM
df
<0.10
<0.05
<0.01
<0.001
1
2.706
3.841
6.635
10.8
2
4.605
5.991
9.210
13.8
3
6.251
7.815
11.345
16.3
4
7.779
9.488
13.277
18.5
5
9.236
11.070
15.086
20.5
6
10.645
12.592
16.812
22.4
8
13.362
15.507
20.090
26.1
10
15.987
18.307
23.209
29.6
12
18.549
21.026
26.217
32.9
20
28.412
31.410
37.566
45.3
25
34.382
37.652
44.314
52.6
Rules for Assigning...
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Q5.1. Which of the following is FALSE? If a genetic disease reduces fertility and the allele that causes the disease offers no other advantage, the allele will likely eventually disappear, due to natural selection. Natural selection does not favor individuals who are homozygous for the sickle- cell allele, because these individuals typically die before they are old enough to reproduce. Individuals who are heterozygous HbA/HbS are protected from malaria, and this is why sickle-cell disease persists in wetter, mosquito-prone regions...
JUST PART B PLEASE AND THANK YOU
TABLE OF CHI SQUARED VALUES. D.F = DEGREES OF FREEDOM
df
<0.10
<0.05
<0.01
<0.001
1
2.706
3.841
6.635
10.8
2
4.605
5.991
9.210
13.8
3
6.251
7.815
11.345
16.3
4
7.779
9.488
13.277
18.5
5
9.236
11.070
15.086
20.5
6
10.645
12.592
16.812
22.4
8
13.362
15.507
20.090
26.1
10
15.987
18.307
23.209
29.6
12
18.549
21.026
26.217
32.9
20
28.412
31.410
37.566
45.3
25
34.382
37.652
44.314
52.6
Rules for Assigning...
A mutation in one of the hemoglobin genes causes sickle cell anemia. The sickle cell allele, S, severely reduces fitness in people who are homozygotes, SS. In contrast, people with at least one normal hemoglobin allele, A, do not suffer the effects of sickle cell anemia, even if the individual is a heterozygote, AS. Interestingly, though, in areas with a high rate of malaria, heterozygotes that carry the sickle cell allele have a higher fitness than do individuals that are...
QUESTION 60 0.33334 points (E "Sickle cell anemia is produced by a genetic defect in the amino acid sequence of hemoglobin. Persons who are homozygous for this allele have abnormal red blood cells, which characterize the disease. The blood cells of heterozygous persons appear normal and they are considered carriers. A test reveals that a man is heterozygous for the sickle cell allele but his wife is homozygous normal. What is the probability of their children will be carriers of...
Sickle-cell Anemia Study Sickle-cell anemia or Sickle-cell disease, is a hereditary disorder. characterized by aryabnormality in the oxygen-carrying hemoglobin molecule in erythrocytes. Sickle-cell conditions have an autosomal recessive pattern of inheritance from parents. The sickle cell defect is a mutation of a single nucleotide of the hemoglobin B gene, which results in glutamic acid being substituted by a different amino acid at position 6. Hemoglobin with this mutation is referred to as Hbs, as opposed to the normal hemoglobin HbA....
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