All of the following regarding sickle cell anemia phenotype is true, except: a. Sickle cell trait...
All of the following regarding sickle cell anemia phenotype is true, except:
| a. |
Sickle cell trait in HbB/HbS heterozygotes gives them resistance to malaria |
|
| b. |
Properties of oxyhemoglobin are severely affected by HbS substitution |
|
| c. |
Both alleles in hemoglobin beta-chain (HbB) gene are mutated in a full-blown condition |
|
| d. |
Solubility of deoxyhemoglobin is decreased |
Homework Answers
1. Answer: Option B is correct
Explanation:
HbA = WT allele
HbS = Mutant allele
HBA/HbA = Normal; Sensitive to Malaria
HBA/HbS = Carrier; Resistant to Malaria
HBS/HbS = Homozygous mutant; Sickle cell anemia
HbS mutation decreases the solubility of deoxyhemoglobin. However, it does not significantly affect the solubility of oxy-hemoglobin.
HbS mutation alters the shape of the protein. It does not alter
some properties such as Oxygen-binding of Hemoglobin.
Add Answer to:
All of the following regarding sickle cell anemia
phenotype is true, except:
a.
Sickle cell trait...
Use the following information to answer the next two questions. Sickle cell anemia is a disease...
Use the following information to answer the next two questions. Sickle cell anemia is a disease that is caused by a mutation in the gene that produces haemoglobin. Hemoglobin carries oxygen in red blood cells. The HbA allele produces normal hemoglobin and the HbS allele produces haemoglobin that sticks together and causes red blood cells to sickle. Heterozygous individuals (HbAHbS) produce both normal and "sickle" hemoglobin so the HbA and HbS alleles are codominant. Heterozygotes do not develop sickle cell...
Sickle-cell Anemia Study Sickle-cell anemia or Sickle-cell disease, is a hereditary disorder. characterized by aryabnormality in...
Sickle-cell Anemia Study Sickle-cell anemia or Sickle-cell disease, is a hereditary disorder. characterized by aryabnormality in the oxygen-carrying hemoglobin molecule in erythrocytes. Sickle-cell conditions have an autosomal recessive pattern of inheritance from parents. The sickle cell defect is a mutation of a single nucleotide of the hemoglobin B gene, which results in glutamic acid being substituted by a different amino acid at position 6. Hemoglobin with this mutation is referred to as Hbs, as opposed to the normal hemoglobin HbA....
A mutation in one of the hemoglobin genes causes sickle cell anemia. The sickle cell allele,...
A mutation in one of the hemoglobin genes causes sickle cell anemia. The sickle cell allele, S, severely reduces fitness in people who are homozygotes, SS. In contrast, people with at least one normal hemoglobin allele, A, do not suffer the effects of sickle cell anemia, even if the individual is a heterozygote, AS. Interestingly, though, in areas with a high rate of malaria, heterozygotes that carry the sickle cell allele have a higher fitness than do individuals that are...
2. Hardy-Weinberg Equilibrium; chi-square test Sickle cell anemia is a recessive disorder caused by a recessive...
2. Hardy-Weinberg Equilibrium; chi-square test Sickle cell anemia is a recessive disorder caused by a recessive mutation (S) in the b-hemoglobin gene. 80% of affected SS individuals die before reproducing. Heterozygotes (AS) and homozygous dominant (AA) individuals do not have sickle cell anemia. The table below shows the number of people of each genotype in a population of 100 people in population of Cameroon. Observed # individuals in a Cameroon population AA AS SS 62 32 6 What are the...
match the conditions and the pathogenic mechanisms Temporary suppression of erythropoiesis following a viral infection (often...
match the conditions and the pathogenic mechanisms
Temporary suppression of erythropoiesis following a viral infection (often a Parvovirus B19 infection in a child) Choose Aplastic anemia resulting from defects in DNA repair mechanisms resulting in increased rates of apoptosis and ineffective erythropoiesis Choose... Sickle Cell Anemia Lack of sufficient iron stores to support erythropoiesis Anemia of Chronic Disease Congenital pure red cell aplasia; likely the result of a failure of red cell progenitors to respond to erythropoietic cytokines Fanconi Anemia...
Temporary suppression of erythropoiesis following a viral infection (often a Parvovirus B19 infection in a child)...
Temporary suppression of erythropoiesis following a viral infection (often a Parvovirus B19 infection in a child) Choose Aplastic anemia resulting from defects in DNA repair mechanisms resulting in increased rates of apoptosis and ineffective erythropoiesis Choose... Sickle Cell Anemia Lack of sufficient iron stores to support erythropoiesis Anemia of Chronic Disease Congenital pure red cell aplasia; likely the result of a failure of red cell progenitors to respond to erythropoietic cytokines Fanconi Anemia Extrinsic Hemolytic Anemia Intravascular or extravascular destruction...
Please check if my answers are correct Temporary suppression of erythropoiesis following a viral infection (often...
Please check if my answers are correct
Temporary suppression of erythropoiesis following a viral infection (often a Parvovirus B19 infection in a child) Transient Erythroblastopenia of Childhood - Aplastic anemia resulting from defects in DNA repair mechanisms resulting in increased rates of apoptosis and ineffective erythropoiesis Fanconi Anemia Lack of sufficient iron stores to support erythropoiesis Iron Deficiency Anemia Congenital pure red cell aplasia; likely the result of a failure of red cell progenitors to respond to erythropoietic cytokines Diamond-Blackfan...
Please, help me with Q 4,5,6. Thanks ! Look for Sickle cell anemia in OMIM and...
Please, help me with Q 4,5,6. Thanks !
Look for Sickle cell anemia in OMIM and answer the following questions: 1. What is the inheritance pattern? 2. Which is/are the gene mutated and its/their chromosomal location (chromosome number and arm)? 3. Which of the following factors affect the severity of the phenotype? (Select all that apply and show a screenshot of the source from which you got your answer) Other genes b. Environmental factors a. Behavioral factors C. d. None...
Q 11. Which of the following statements is TRUE about Sickle cell anemia? (A) It is...
Q 11. Which of the following statements is TRUE about Sickle cell anemia? (A) It is caused by a genetic mutation in the beta-hemoglobin gene. (B) It confers heterozygote advantage against malaria (C) It results in abnormal, sickle-shaped erythrocytes. (D) All of the above. Q 12. Which of the following explains why a deleterious allele may persist in a population? (A) Random genetic drift (B) Balancing selection (C) Negative selection (D) Random genetic drift or balancing selection Q 13. Which...
My Study on Sickle Cell Anemia Research In 500 words, answer the following questions 1.Select your...
My Study on Sickle Cell Anemia Research In 500 words, answer the following questions 1.Select your study sample 2. How have you selected your sample? 3. How will you select your sample population and give the rationale behind your decision Please type the solution on the keyboard so that I can copy and paste Q. No 1. Answer : Sickle cell disease : It is defined as it is a chronic heriditory form of Anemia, in which the red blood...
Sickle-cell Anemia Study Sickle-cell anemia or Sickle-cell disease, is a hereditary disorder. characterized by aryabnormality in the oxygen-carrying hemoglobin molecule in erythrocytes. Sickle-cell conditions have an autosomal recessive pattern of inheritance from parents. The sickle cell defect is a mutation of a single nucleotide of the hemoglobin B gene, which results in glutamic acid being substituted by a different amino acid at position 6. Hemoglobin with this mutation is referred to as Hbs, as opposed to the normal hemoglobin HbA....
A mutation in one of the hemoglobin genes causes sickle cell anemia. The sickle cell allele, S, severely reduces fitness in people who are homozygotes, SS. In contrast, people with at least one normal hemoglobin allele, A, do not suffer the effects of sickle cell anemia, even if the individual is a heterozygote, AS. Interestingly, though, in areas with a high rate of malaria, heterozygotes that carry the sickle cell allele have a higher fitness than do individuals that are...
match the conditions and the pathogenic mechanisms
Temporary suppression of erythropoiesis following a viral infection (often a Parvovirus B19 infection in a child) Choose Aplastic anemia resulting from defects in DNA repair mechanisms resulting in increased rates of apoptosis and ineffective erythropoiesis Choose... Sickle Cell Anemia Lack of sufficient iron stores to support erythropoiesis Anemia of Chronic Disease Congenital pure red cell aplasia; likely the result of a failure of red cell progenitors to respond to erythropoietic cytokines Fanconi Anemia...
Temporary suppression of erythropoiesis following a viral infection (often a Parvovirus B19 infection in a child) Choose Aplastic anemia resulting from defects in DNA repair mechanisms resulting in increased rates of apoptosis and ineffective erythropoiesis Choose... Sickle Cell Anemia Lack of sufficient iron stores to support erythropoiesis Anemia of Chronic Disease Congenital pure red cell aplasia; likely the result of a failure of red cell progenitors to respond to erythropoietic cytokines Fanconi Anemia Extrinsic Hemolytic Anemia Intravascular or extravascular destruction...
Please check if my answers are correct
Temporary suppression of erythropoiesis following a viral infection (often a Parvovirus B19 infection in a child) Transient Erythroblastopenia of Childhood - Aplastic anemia resulting from defects in DNA repair mechanisms resulting in increased rates of apoptosis and ineffective erythropoiesis Fanconi Anemia Lack of sufficient iron stores to support erythropoiesis Iron Deficiency Anemia Congenital pure red cell aplasia; likely the result of a failure of red cell progenitors to respond to erythropoietic cytokines Diamond-Blackfan...
Please, help me with Q 4,5,6. Thanks !
Look for Sickle cell anemia in OMIM and answer the following questions: 1. What is the inheritance pattern? 2. Which is/are the gene mutated and its/their chromosomal location (chromosome number and arm)? 3. Which of the following factors affect the severity of the phenotype? (Select all that apply and show a screenshot of the source from which you got your answer) Other genes b. Environmental factors a. Behavioral factors C. d. None...
Q 11. Which of the following statements is TRUE about Sickle cell anemia? (A) It is caused by a genetic mutation in the beta-hemoglobin gene. (B) It confers heterozygote advantage against malaria (C) It results in abnormal, sickle-shaped erythrocytes. (D) All of the above. Q 12. Which of the following explains why a deleterious allele may persist in a population? (A) Random genetic drift (B) Balancing selection (C) Negative selection (D) Random genetic drift or balancing selection Q 13. Which...
Most questions answered within 3 hours.
-
Little’s Law: Val d’Costa is a world famous ski village in the
French Alps. Because of...
asked 23 minutes ago -
Find the absolute error D for the calculation if A + B/C=D A=
9.4 +/- 0.4...
asked 36 minutes ago -
New Air Heating and Cooling, manufactures furnaces and central
air units. The company pride itself on...
asked 50 minutes ago -
A coach uses a new technique to train gymnasts. Seven
gymnasts were randomly selected and their...
asked 2 hours ago -
While rotating the tires on your car you notice a rock [mass =
0.1 Kg] stuck...
asked 4 hours ago -
Using MARS simulator, write MIPS programs according to
the following scenarios: Receive a positive integer number...
asked 6 hours ago -
An object in front of a concave mirror has a real image that is
11.5 cm...
asked 6 hours ago -
Consider the reaction, C3 H8 + O2 --> CO2 + H2O. How many
moles of O2...
asked 8 hours ago -
You and your opponent both roll a fair die. If you both roll the
same number,...
asked 8 hours ago -
In a study of the accuracy of fast food drive-through orders,
Restaurant A had 257 accurate...
asked 8 hours ago -
Identify and describe in detail the four categories of
institutions that could be included in a...
asked 8 hours ago -
In python
class Customer:
def __init__(self, customer_id, last_name, first_name, phone_number, address):
self._customer_id = int(customer_id)
self._last_name =...
asked 9 hours ago