Question

Temporary suppression of erythropoiesis following a viral infection (often a Parvovirus B19 infection in a child) Choose Aplastic anemia resulting from defects in DNA repair mechanisms resulting in increased rates of apoptosis and ineffective erythropoiesis Choose... Sickle Cell Anemia Lack of sufficient iron stores to support erythropoiesis Anemia of Chronic Disease Congenital pure red cell aplasia; likely the result of a failure of red cell progenitors to respond to erythropoietic cytokines Fanconi Anemia Extrinsic Hemolytic Anemia Intravascular or extravascular destruction of RBCs caused by something in the RBC environment such as parasites, chemicals, lipid abnormalities, or immune-mediated destruction Decreased solubility of a mutated hemoglobin leading to formation of intraerythrocytic crystals, mild chronic hemolysis due to removal of crystal-containing RBCs by the spleen Beta Thalassemia Alpha Thalassemia Stored iron is present, but can not be mobilized at the same rate as erythropoiesis Hemoglobin C Disease Substitution of a nonpolar valine for polar glutamic acid as a result of a mutation in the HBB gene, resulting in decreased solubility of deoxyhemoglobin S, polymerization of the hemoglobin molecule, oxidative damage to red cell membrane, failure of membrane cation pumps, and formation of drepanocytes Porphyrias Reduced synthesis of alpha-globin chains (and subsequent accumulation of excess beta-chains in the red cell) Transient Erythroblastopenia of Childhood Diamond-Blackfan Intrinsic Hemolytic Anemia Extravascular destruction of RBCs due to something inherent to the RBCs such as membrane defects, enzyme deficiencies, or abnormal hemoglobins Group of conditions caused by defects affecting enzymatic steps of heme synthesis OTHER than production of 5. aminolevulinic acid Stored iron is sequestered; inflammatory cytokines induce high levels of hepcidin expression Megaloblastic Anemia Sideroblastic Anemia Reduced synthesis of beta-globin chains (and subsequent accumulation of excess alpha-globin chains Functional Iron Deficiency Defect in DNA synthesis due to a folate or cobalamin (Vitamin B12) deficiency Iron Deficiency Anemia Defect in the production of 5-aminolevulinic acid due to the impact of gene mutations, toxins (lead), etc. on aminolevulinic acid synthase-2 (ALAS2) Choose...

match the conditions and the pathogenic mechanisms

Answer 1

Ans.)

• Lack of sufficient iron store to support erythropoiesis – Iron deficiency Anemia
• Congenital pure red cell aplasia - Blackfan–Diamond
• Intravascular or extra vascular destruction of RBC caused by something in the RBC environment such as parasite, chemical and lipid abnormalities ….. – Extrinsic Hemolytic Anemia
• Stored iron is present but cannot be mobilized as the same rate erythropoisis – Functional Iron deficiency
• Decreased solubility of a mature hemoglobin leading to the formation of intraerythrocytic crystal, mild chronic hemolysis due to normal crystal containing RBC by the spleen – Sideroblastic anemia
• Reduced synthesis of alpha globin chain - Alpha-thalassemia
• Reduced synthesis of beta globin chain - Beta-thalassemia