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1. What is the mechanism of drug release from PEG suppositories? 2. What is the rationale...

1. What is the mechanism of drug release from PEG suppositories?

2. What is the rationale for recommending that patients moisten PEG suppositories prior to insertion?

3. Why is the double-casting method used to prepare the suppositories?

4. How to calibrate a suppository mold? Briefly explain the procedure.

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Answer #1

1 PEG suppositories dissolves in body fluids and does not leak from the orifice.

2 PEG bases require dissolution for release of the drug from the dosage form so systemic depends on the amount of fluid present in at site.

3 The reason is that the density factor for the drug in the base is not reported.

4 The first step is to prepare moulded suppositories from base material.After removal from the mould,the suppositories are weighed and the total weight and average weight of each suppository are recorded.To determine the volume of the mould,the suppositories are carefully melted in a caliberated beaker and the volume of the melt is determined for the total number as well as for the a avrage of one suppository.

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