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, acts on the hypothalamus causing it Fever is initiated when a substance in circulation, called a(n) to reset body temperatu
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Fever is initiated when a substance called pyrogen acts on the hypothalamus causing it to set the body temperature at a higher setting.

Pyrogen (As they are endotoxins, which are lipopolysaccharides (LPS) that affect the hypothalamus and reset the body temperature)

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