Question

Instructor - "Consider objective "6. Explain the statement "The dose makes the poison" and the definition of lethal dose 50% (LD50). Chemical A has a dermal LD50 of 5 mg/kg while Chemical B has a dermal LD50 of 350 mg/kg. In both cases, dermal stands for skin exposure and the units mg/kg mean mg of chemical per kilogram of bodyweight. Use the information to rank these four situations from most severe danger (1) to least severe danger (4)." Some powder of A spilled on the hands (several milligrams). Some powder of B spilled on the hands (several milligrams). A scoop of A spilled on the hands (several grams) A scoop of B spilled on the hands (several grams).

Answer 1

DATE PAGE NO The dose makes the poison" is a phrase used to indicate a basic principle of toxicology lat means that a substance can give the harmful effect (associated with its toxic property only if reaches a susceptible blological system inside the body at a high enough concentration/ dose leven water & oxygen is eaten or drunk exars quantity can be Inhale or toxtc if it in

TOATE 1 20 .PAGE NO LD 50 is basically a general indicatos of a substances acute toxicity It is expressed as mars of substance administered per unit man of test subject smount is expressed as mg of substance per kg of body mass LD50 5 mg / kg Chemica A B 2050 350mg / kg. bermal LD 50 5mg / kg means 5 mg of that Chemical for every 1kg body weight, when administered in one dose by dermal, causes the death of 50% of the test quoup for surnal LD50 5mg or less 5-43 44-340 350-2810 28 20-22 590 22600 or more Extremly Toxic Highly Toxic Moderately Toxic. Slighilly TOXIC practically Non Toxic. Relatively Harmless

DATE : J PAGE NO 2050 of 5mg/kg is more dangerous than 2050 of 350 mg/kg Chemical A Chemical B (dangerous) Seural mg -Seweral 9 (dangerous) Chanical A Chemical B > Chemicae A y Chemical gm &m) gma of Chemical A = 1000mg x 5 mg 5000mg les toxic