Question

Discuss drug therapy and surgical management utilized in Ménière's disease

Answer 1

ANSWER.

* Meniere's disease.

         It is an abnormal condition of ear in which excess circulatory fluid

         in the inner ear due to malabsorption in the endolymphatic sac or

         blockage in the duct.

* Drug therapy for management of meniere's disease.

           * Pharmacological therapy.

                   * Tranquilizers.

                          Used to control vertigo associated with this disease.

                          Eg ; Diazepam.Clonazepam.

                   * Antihistamines.

                          Used to suppress the vestibular system.

                            Eg ; Meclizine,Dimenhydrinate.

                   * Antiemetics.

                           This drugs are used to control nausea,vomiting and vertigo

                            associated with this disease.

                              Eg ; Promethazine.Domperidone.

                   * Vasodilators.

                            Used to reduce pressure in the inner ear system.

                               Eg ; Amlodipine,Nifedipine.

                   * Diuretics.

                           Used to lower pressure in the endolymphatic system.

                                 Eg ; Furosemide,mannitol.

          * Surgical Management.

                 If the drug therapy is not effective then surgical procedures are

                 used to treat this condition.

               Common surgical procedures used in meniere's disease are

                    * Endolymphatic sac surgery.

                             Surgical procedure in which a small amount of bone is removed

                             the surrounding area of endolymphatic sac to reduce pressure of

                             the fluid in the sac.

                    * Labyrinthectomy.

                            It is the surgical removal of labyrinth to treat meniere's disease.

                    * Intratympanic Gentamicin and steroids.

                            Steriods and gentamicins are injected into the inner ear through

                            tympanic membrane to destroy cells of balance and produce anti

                            inflammatory effects.

                    * Vestibular neurectomy.

                            It is a surgical procedure in which surgeon remove nerves of balance

                            and preserving the hearing nerve.