Question

Sickle cell disease is an autosomal recessive disease. Homozygous dominant (SS) and heterozygous (Ss) individuals will be non-diseased, but homozygous recessive (ss) individuals will have the disease. A study of sickle cell disease in New York found that in a one year period:

• 1/1146 of all infants in the state were born with sickle cell disease
• 1/230 non-hispanic black infants were born with sickle cell disease
• 1/41,647 non-hispanic white infants were born with sickle cell disease
• 1/2,320 hispanic infants were born with sickle cell disease

Based on this information:

1) You would estimate that the frequency of the dominant allele in the total population of New York, based on all infants born in the state, would be approximately:

0

0.03

0.29

0.67

0.97

2) You would estimate that the frequency of the recessive allele in a population of non-hispanic whites would be approximately:

0

0.03

0.00002

0.004

0.99998

0.996

3) You would estimate that the frequency of carriers for the disease (Ss) in a population of non-hispanic black individuals would be approximately:

0

1/4

1/8

1/100

1/8000

4) You would estimate that the frequency of homozygous dominant (SS) in a population of hispanic individuals would be approximately:

0

0.959

0.041

0.783

0.061

5) You would estimate that the frequency of heterozygotes (Ss) in a population of hispanic individuals would be approximately:

0

1/24

1/4

1/150

1/900

Answer 1

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