In addition to the alpha 1 and beta 1 adrenergic receptor blocker, how else can adrenergic activity be inhibited?
Other than alpha 1 and beta 1 adrenergic receptor blockers , there are some more antiadrenergic activities are there which are as follows:
1. Alpha 2 adrenergic agonists
2. Monoamine depleting agents
Alpha 2 adrenergic agents : These are a catagory of sympathomimetic which activates the alpha 2 receptors . Alpha 2 receptors are associated with sympatholytic properties and are present in presynaptic neurons. Activating alpha 2 receptors inhibits the adenylyl cyclase which inturn reduces the level of cyclic adenosine monophosphate . This prevents the calcium ions from entering the nerve terminal that's results in sullressupp of neural firing. This inhibits norepinephrine release that decreases the activity of a sending noradrenergic pathways.
2. Monoamine depleting agents: these agents inhibits the uptake of catacholamines into presynaptic vesicles of adrenergic neurons that reduces the release of same .usually monoamines metabolize the catacholamines that are not bound to the receptors by reuptaking it into the presynaptic nerve fibres. The depletion of monoamines degrades the catacholamines after reuptaking.
In addition to the alpha 1 and beta 1 adrenergic receptor blocker, how else can adrenergic...
Effects of sympathetic (adrenergic) receptor stimulation & blocking Receptor Location Adrenergic Adrenergic blocker Alpha 1 Eye Arterioles of skin, organs & mucous membranes Veins Male Sex Organs Prostate Capsule Alpha 2 Presynaptic nerve terminals Beta 1 Heart Kidney Beta 2 Arterioles of heart, lungs, and skeletal muscle Bronchi Uterus Liver Skeletal muscle
Epinephrine is a ligand for the beta-adrenergic receptor. When activated the beta-adrenergic receptor undergoes a conformational change that results in the activation of the G protein GsLaTeX: \alpha α . Which of the following secondary messengers would you expect to be increased when epinephrine binds to a beta-adrenergic receptor? DAG cGMP cAMP Ca2+ phospholipase C IP3
09. Which of the following beta-blocker is also a alpha-receptor blocker? A) Timolol B) Carvedilol C) Pindolol D) Propranolol Q10. Which of the following are beta1/beta2-adrenoceptor antagonists? Propanolol?/ Pindolol? both?
There are two main types of adrenergic receptor: the alpha and beta-adrenoceptors. Noradrenaline shows slight selectivity for the alpha-receptor, whereas isoprenaline shows selecivity for the Beta-adrenoceptor. Adrenaline shows no selectivity and binds equally well to both the alpha and beta adrenoceptors. Suggest an explanation for these differences in selectivity.
Doxazosin is an antihypertensive drug of the alpha-1 adrenergic blocker type. If a patient is taking 10 mg/day and the supply consists entirely of 100 2-mg tablets, for how many days will the patient’s supply of doxazosin tablets last?
What does it mean if a beta blocker is classified as cardioselective? It's selective for what receptor? What is the overall effect of adreneric drugs on the heart and cardiovascular system? What is the overall effect of adrenergic drugs on the eye? What is the overall effect of adrenergic drugs on bronchial smooth muscle? What is the overall effect of adrenergic drugs on the urinary bladder? What is an important potential toxicity of atropine and other muscarinic antagonists in infants...
There are two main types of adrenergic receptors: the alpha and beta adrenoceptors. Noradrenaline shows slight selectivitty for the alpha receptor, whereas isoprenaline shows selectivity for the beta adrenoceptor. Adrenaline shows no selectivity and binds equally well to both the alpha and beta forms of the adrenoceptors. Draw the chemical structures for noradrenaline, isoprenaline, and adrenaline. suggest an explanation for these differencse in selectivity relative to the binding site of each receptor.
Select the right answer Question 1: Carvedilol is an example of a beta-adrenergic blocker a) True b) False Question 2: Glyceryl trinitrate is available in which of the following dosage forms? a) Sublingual Tablet b) Transdermal patch c) Sublingual spray d) all of the above Question 3: ACE inhibitors are useful in treating hypertension by reducing the levels of the powerful vasoconstrictor angiotension II. The dry cough associated with their use in some patients occurs due to : a) Inhibition...
Q5. Which of the following beta-2 adrenergic receptor-selective agonist(s):may be used in management of both chronic and acute asthma? A) Ritodrine & Terbutaline B) Terbutaline & Albuterol C) Ritodrine & Propranolol D) Timolol & Propranolol Q6. What is the primary pharmacological action of Rivastigmine? A) AChE activator b) AChE inhibitor C) NMDA receptor blocker neuroinflammation D) Inhibitor of
2. Describe the main direct and indirect effects of alpha- and beta-adrenergic blockers (antagonists) on the structures listed in the preceding objective and on stated sympathetic/adrenergic responses. 3. Describe the adverse effects of alpha blockade and compare them with the adverse effects of beta blockade. 4. Describe the physiologic changes that affect blood pressure and other aspects of cardiovascular function as the patient goes from the supine to the standing position; also, explain the impact of alpha- and beta-adrenergic blockers...