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In addition to the alpha 1 and beta 1 adrenergic receptor blocker, how else can adrenergic...

In addition to the alpha 1 and beta 1 adrenergic receptor blocker, how else can adrenergic activity be inhibited?
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Answer #1

Other than alpha 1 and beta 1 adrenergic receptor blockers , there are some more antiadrenergic activities are there which are as follows:

1. Alpha 2 adrenergic agonists

2. Monoamine depleting agents

Alpha 2 adrenergic agents : These are a catagory of sympathomimetic which activates the alpha 2 receptors . Alpha 2 receptors are associated with sympatholytic properties and are present in presynaptic neurons. Activating alpha 2 receptors inhibits the adenylyl cyclase which inturn reduces the level of cyclic adenosine monophosphate . This prevents the calcium ions from entering the nerve terminal that's results in sullressupp of neural firing. This inhibits norepinephrine release that decreases the activity of a sending noradrenergic pathways.

2. Monoamine depleting agents: these agents inhibits the uptake of catacholamines into presynaptic vesicles of adrenergic neurons that reduces the release of same .usually monoamines metabolize the catacholamines that are not bound to the receptors by reuptaking it into the presynaptic nerve fibres. The depletion of monoamines degrades the catacholamines after reuptaking.

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