what does telomerase enable cancer cells to do the normal adult somatic cells cannot do?
what does telomerase enable cancer cells to do the normal adult somatic cells cannot do?
Homework Answers
Ans) Telomeres, repetitive (TTAGGG) DNA–protein complexes at the ends of chromosomes, are crucial for the survival of cancer cells. They are maintained by an enzyme called telomerase in the vast majority of tumors. Telomeres protect chromosome ends from fusion and from being recognized as sites of DNA damage.
- Telomerase is a ribonucleoprotein DNA polymerase complex that maintains telomere length. Telomerase activity is absent in most normal human somatic cells because of the lack of expression of TERT; TERC is usually present. On the other hand most mouse cells have telomerase activity.
Add Answer to:
what does telomerase enable cancer cells to do the
normal adult somatic cells cannot do?
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Cancer Biology
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Explain the significance of telomerase expression in cancer cells
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Cancer Biology
8. Re-expression of telomerase can confer immortality to emerging clones of tumor cells, and was originally viewed as an attractive target for drug discovery. However, which of the following best explains the lack of therapeutic efficacy for telomerase inhibitors? a. Telomerase alone is sufficient for transformation in human cells. b. Telomerase is required for the maintenance of somatic cell populations. c. Too many post-inhibition cell doublings would be required to see anti-tumor efficacy. d. Telomerase has sequence and...
Chapter TEN: Living with Cancer and other Chronic Diseases Questions: 1. What properties do cancer cells possess that are lacking in normal cells? 2. What are the principal factors that contribute to the development of lung cancer? 3. What are the principal factors that contribute to the development of breast cancer? When should regular mammography begin, and which women should begin using it earliest? 4. What are the risk factors, symptoms and treatment for testicular cancer? 5. What signs indicate...
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