Question

3. (3 Pt) Describe one technological challenge in creating artificial pancreas. making an artificial pancreas fanctions, work with the how?

Answer 1

Ans) Technological Challenge in creating artificial pancreas:

- Diabetes is a complex disease that requires intensive individualized intervention and management.

- Since the independent introduction of wearable insulin pumps and subcutaneous glucose sensors, the goal has been to link these two technologies and assist patients in achieving near-normal blood glucose to prevent chronic complications while avoiding the acute complications of hypoglycemia and severe hyperglycemia.

- This FDA approval represents technologic progress toward an artificial pancreas, but is not the complete answer.

- Despite the advancement in technology, the patient still has the essential role of delivering the correct premeal bolus at the appropriate time to achieve postprandial glucose control.

- This importance is highlighted by the elevation of postprandial glucose contributing disproportionately to the elevation in HgbA1c in patients with values greater than 7%.

- Future developments toward ease of use, more efficacious mealtime control and increased accuracy of sensors are required and must include pediatric patients before an artificial pancreas can be a reality.

- Artificial pancreas: working:
The pancreas regulates glucose levels in the blood. Clusters (islets) of endocrine pancreatic (β) cells lower glucose levels by increasing insulin hormone levels, opening the glucose receptors in cells. In 1969 an implantable insulin pump was developed at the University of Minnesota.