Question

Aspirin - Peptic Ulcer PQ, a 72-year-old woman, has taken 650 mg of aspirin four times a day for 8 months to alleviate her symptoms of pain and inflammation associated with arthritis. Four weeks ago a peptic ulcer developed. 1. Explain the process in which PQ could have a peptic ulcer. How could this have been prevented? 2. Compare the similarities and differences in the side effects of salicylates with those of acetic acid agents, propionic acid agents, COX-2 inhibitors, and phenylatic acid. 3. What patient teaching points should PQ receive before and during the time she takes the aspirin? perti er 4. How woul COx-2 r 5. Would DMARD's be more helpful in aleviating PO's symptoms? Explain your answer. 6. Compare the differences in the various types of DMARDs Reviewed 11/18

Answer 1

1.

Peptic ulcer is the sore in the intestines.

Normally the walls of the GI tract is protected by mucus layer secreted from the goblet cells. This mucus layer protects the walls of GIT from the destruction due to acids secreted by parietal cells.

Most common causes for peptic ulcers are H.pylori first leading cause, second leading cause is extreme use of NSAIDs for long time in the treatment of arthritis.

Asprin is the NSAIDs that develops Peptic ulcer in PQ person.

The process of Aspirin causes peptic ulcer in PQ is as follows:-

• Aspirin prevent mucus production from goblet cells, so that the protective layer of GIT is removed.
• And asprin also increases acid secretion from parietal cells, so that prolonged use of asprin developed peptic ulcer in PQ.

Prevention of peptic ulcer in this patient is possible with the following measurements.

• Use an antacid along with NSAIDs treatment.
• Instruct the patient to consume asprin with full stomach. So that the acids are neutralized.
• Advice to stop the prolonged usage of NSAIDs.